Evidence map›Paper›PMID 35174441›Full record

ArticleAnnals of nuclear medicine2022

Voxel-based analysis of age and gender effects on striatal [

Yoko Shigemoto, Hiroshi Matsuda, Yukio Kimura, Emiko Chiba, Masahiro Ohnishi, Moto Nakaya, Norihide Maikusa, Masayo Ogawa, Yohei Mukai, Yuji Takahashi and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of nuclear medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Yoko ShigemotoDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Hiroshi MatsudaDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan. hiroshi.matsuda@mt.strins.or.jp.ORCID http://orcid.org/0000-0002-6297-9897
Yukio KimuraDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Emiko ChibaDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Masahiro OhnishiDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Moto NakayaDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Norihide MaikusaDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Masayo OgawaDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Yohei MukaiDepartment of Neurology, National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Yuji TakahashiDepartment of Neurology, National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Kazuya SakoDepartment of Neurology, Nakamura Memorial Hospital, Sapporo, Japan.
Hiroshi ToyamaDepartment of Radiology, Fujita Health University, Toyoake, Japan.
Yoshitaka InuiDepartment of Radiology, Fujita Health University, Toyoake, Japan.
Yasuyuki TakiDepartment of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Hiroshi NagayamaDepartment of Neurology, Graduate School of Medicine, Nippon Medical School Bunkyo-Ku, Tokyo, Japan.
Kenjiro OnoDivision of Neurology, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Atsushi KonoDepartment of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
Kenji SekiguchiDivision of Neurology, Kobe University Graduate School of Medicine, Kobe, Japan.
Shigeki HiranoDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Noriko SatoDepartment of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
National Center of Neurology and Psychiatry · JPFujita Health University · JPKobe University · JPChiba University · JPKanazawa University · JPMitsubishi Research Institute (Japan) · JPNakamura Memorial Hospital · JPNippon Medical School · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAlthough previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a conventional regions of interest-based analysis. Here, we investigated age and gender effects on striatal DaT binding at the voxel level, using a multicenter database of [(

methodsWe used the Southampton method to calculate the specific binding ratios (SBRs) of each subject's striatum and then converted the [

resultsWhen all subjects were explored as a group, DaT binding throughout the striatum decreased with advancing age. Among all subjects, the females showed higher DaT binding in the bilateral caudate compared to the males. In the young to middle-aged subjects, the females showed higher DaT binding throughout the striatum (with a slight caudate predominance) versus the males. In the elderly, there were no gender differences in striatal DaT binding.

conclusionOur findings of striatal subregional age- and gender-related differences may provide useful information to construct a more detailed DaT database in healthy Japanese subjects.

Indexed as

Dopamine Plasma Membrane Transport ProteinsIodine RadioisotopesAdultAgedFemaleHumansJapanMaleMiddle AgedTomography, Emission-Computed, Single-PhotonTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneDopamine Plasma Membrane Transport ProteinsIodine-123Iodine RadioisotopesTropanes[123I] FP-CITAgingDopamineGenderSPECTVoxel-based analysis

Identifiers

PMID35174441
OpenAlexW4213378012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.