Evidence map›Paper›PMID 35174258›Full record

ArticleOptica2021

Weakly supervised individual ganglion cell segmentation from adaptive optics OCT images for glaucomatous damage assessment.

Somayyeh Soltanian-Zadeh, Kazuhiro Kurokawa, Zhuolin Liu, Furu Zhang, Osamah Saeedi, Daniel X Hammer, Donald T Miller, Sina Farsiu

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Optica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05370287 (Adaptive Optics Retinal Imaging), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05370287 narecruitingnot on this map

Adaptive Optics Retinal Imaging

TypeinterventionalSponsorFood and Drug Administration (FDA)Ran2018 to 2028Enrolled150ConditionsGlaucoma, Primary Open AngleArmsoxygen inhalation, Adaptive optics imaging
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Cumulative Loss of Inner Retinal Neurons in Healthy and Glaucoma Subjects.Investigative ophthalmology & visual science · 2026
    Article
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  8. Review
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  15. Article
  16. Biomedical optics express · 2024
    Article
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  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Somayyeh Soltanian-ZadehDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
Kazuhiro KurokawaSchool of Optometry, Indiana University, Bloomington, Indiana 47405, USA.
Zhuolin LiuCenter for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA.ORCID 0000-0001-8019-2054
Furu ZhangCenter for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA.
Osamah SaeediDepartment of Ophthalmology and Visual Sciences, University of Maryland Medical Center, Baltimore, Maryland 21201, USA.
Daniel X HammerCenter for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA.ORCID 0000-0003-0532-1914
Donald T MillerSchool of Optometry, Indiana University, Bloomington, Indiana 47405, USA.
Sina FarsiuDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.ORCID 0000-0003-4872-2902
Center for Devices and Radiological Health · USDuke University · USIndiana University · USUniversity of Maryland, Baltimore · US

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Optical Imaging of the Photoreceptor-RPE ComplexR01EY018339 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI MILLER, DONALD T · 2007 to 2025
$7.7M
Quantitative assessment of glaucomatous conventional outflow dynamicsR01EY030124 · NEI · DUKE UNIVERSITY · PI C ROSS ETHIER, Sina Farsiu · 2019 to 2026
$4.0M
Imaging spatial and temporal dynamics of retinal ganglion cellsR01EY029808 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI MILLER, DONALD T · 2019 to 2022
$1.7M
Role of Capillary Flow and Autoregulation in Primary Open Angle GlaucomaK23EY025014 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI SAEEDI, OSAMAH JAWAID · 2015 to 2019
$1.0M
Handheld Portable Adaptive Optics Optical Coherence Tomography for Imaging Young ChildrenR21EY029804 · NEI · DUKE UNIVERSITY · PI FARSIU, SINA, IZATT, JOSEPH A · 2019 to 2020
$424k
NEI NIH HHS K23 EY025014NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY018339NEI NIH HHS R01 EY029808NEI NIH HHS R01 EY030124NEI NIH HHS R21 EY029804
6 · The paper itself

Abstract

Cell-level quantitative features of retinal ganglion cells (GCs) are potentially important biomarkers for improved diagnosis and treatment monitoring of neurodegenerative diseases such as glaucoma, Parkinson's disease, and Alzheimer's disease. Yet, due to limited resolution, individual GCs cannot be visualized by commonly used ophthalmic imaging systems, including optical coherence tomography (OCT), and assessment is limited to gross layer thickness analysis. Adaptive optics OCT (AO-OCT) enables

Identifiers

PMID35174258
PMCPMC8846574
OpenAlexW3136416453

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.