ArticleFrontiers in nutrition2021
Association of Vitamin K Insufficiency With Cognitive Dysfunction in Community-Dwelling Older Adults.
Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial.Drug design, development and therapy · 2025Trial
- Associations between dietary vitamin K1 and K2 intake and incident dementia: findings from the Danish Diet, Cancer, and Health cohort.European journal of nutrition · 2026Article
- Warfarin Treatment is Associated With Lower Postmortem Brain Vitamin K Concentrations in Older Adults.The Journal of nutrition · 2025Article
- Roles of osteocalcin in the central nervous system.CNS neuroscience & therapeutics · 2024Review
- Dietary vitamin K intake is associated with decreased neurofilament light chain among middle-aged and older adults from the NHANES.Frontiers in nutrition · 2024Article
- Vitamin K insufficiency predicts incidence of frailty in community-dwelling older adults: The Otassha Study.Journal of bone and mineral metabolism · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin K is a fat-soluble vitamin shown to be associated with several age-related diseases. Although a small number of epidemiological studies described the relationship between vitamin K status and cognitive impairment, vitamin K status was estimated by relatively special methods in previous reports. Here, we demonstrated the association of the concentration of undercarboxylated osteocalcin (ucOC) in serum, which is a biomarker for vitamin K insufficiency, with cognitive function in a cross-sectional study. A total of 800 community-dwelling older adults (mean age = 75.9) were invited to geriatric health examination, including a Mini-Mental State Examination (MMSE) and a blood test. By using binary logistic regression analysis, the risk of cognitive impairment equivalent or below the mild cognitive impairment level for each tertile of ucOC was examined, with the lowest tertile as the reference. We found a significant association of impaired cognitive function and concentration of ucOC in the highest tertile of ucOC, with the odds ratio of 1.65 (95% CI, 1.06 to 2.59,
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