Evidence map›Paper›PMID 35174044›Full record

ArticleGlobal heart2022

Hypertension and Socioeconomic Status in South Central Uganda: A Population-Based Cohort Study.

Aishat Mustapha, Joseph Ssekasanvu, Ivy Chen, Mary Kathryn Grabowski, Robert Ssekubugu, Godfrey Kigozi, Steven J Reynolds, Ronald H Gray, Maria J Wawer, Joseph Kagaayi and 2 more

Abstract read
In one paragraph

Article in Global heart, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  7. Hypertension risk perception among young adults in Victoria University Kampala Uganda.International journal of cardiology. Cardiovascular risk and prevention · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aishat MustaphaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.ORCID 0000-0001-6995-2323
Joseph SsekasanvuRakai Health Sciences Program, Kalisizo, Uganda.ORCID 0000-0002-3721-2299
Ivy ChenDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.
Mary Kathryn GrabowskiRakai Health Sciences Program, Kalisizo, Uganda.ORCID 0000-0002-4451-3436
Robert SsekubuguRakai Health Sciences Program, Kalisizo, Uganda.ORCID 0000-0003-1245-4774
Godfrey KigoziRakai Health Sciences Program, Kalisizo, Uganda.
Steven J ReynoldsRakai Health Sciences Program, Kalisizo, Uganda.ORCID 0000-0002-5403-2759
Ronald H GrayRakai Health Sciences Program, Kalisizo, Uganda.ORCID 0000-0003-1952-6507
Maria J WawerRakai Health Sciences Program, Kalisizo, Uganda.ORCID 0000-0002-3601-4469
Joseph KagaayiRakai Health Sciences Program, Kalisizo, Uganda.ORCID 0000-0003-4101-3038
Larry W ChangRakai Health Sciences Program, Kalisizo, Uganda.ORCID 0000-0001-7985-4567
Wendy S PostDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-8655-5204

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
International Center for Excellence in Research (ICER) in Uganda: Impact of ARVsZIAAI001040 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REYNOLDS, STEVEN · 2009 to 2025
$23.5M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Epidemiology and Impact of the HIV, NCD, and Urbanization Syndemic in AfricaR01HL152813 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2021 to 2025
$7.8M
Multidisciplinary Research Training to Understand and Reduce HIV Incidence in UgandaD43TW010557 · FIC · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2018 to 2022
$1.6M
FIC NIH HHS D43 TW010557NHLBI NIH HHS R01 HL152813NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 HL107275
6 · The paper itself

Abstract

Background: Limited studies exploring the impact of socioeconomic status (SES) on hypertension in Africa suggest a positive association between higher SES and hypertension. The economic development in sub-Saharan African countries has led to changes in SES and associated changes in lifestyle, diet, and physical activity, which may affect the relationship between hypertension and SES differently compared with higher income countries. This cross-sectional study from a large population-based cohort, the Rakai Community Cohort Study (RCCS), examines SES, hypertension prevalence, and associated risk factors in the rural Rakai Region in south-central Uganda. Methods: Adults aged 30-49 years residing in 41 RCCS fishing, trading, and agrarian communities, were surveyed with biometric data obtained between 2016 and 2018. The primary outcome was hypertension (systolic blood pressure (BP) ≥ 130 mmHg or diastolic BP ≥ 80 mmHg). Modified Poisson regression assessed the adjusted prevalence ratios (PR) of hypertension associated with SES; body mass index (BMI) was explored as a potential mediator. Results: Among 9,654 adults, 20.8% had hypertension (males 21.2%; females 20.4 %). Participants with hypertension were older (39.0 ± 6.0 vs. 37.8 ± 5.0; p < 0.001). Higher SES was associated with overweight or obese BMI categories (p < 0.001). In the multivariable model, hypertension was associated with the highest SES category (aPR 1.23; confidence interval 1.09-1.38; p = 0.001), older age, male sex, alcohol use, and living in fishing communities and inversely associated with smoking and positive HIV serostatus. When BMI was included in the model, there was no association between SES and hypertension (aPR 1.02; CI 0.90-1.15, p = 0.76). Conclusion: Hypertension is common in rural Uganda among individuals with higher SES and appears to be mediated by BMI. Targeted interventions could focus on lifestyle modification among highest-risk groups to optimize public health impact. Key Messages:

Indexed as

HypertensionAdultCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsSocial ClassSocioeconomic FactorsUgandacardiovascular diseaseglobal cardiovascular diseaseHypertensionRakaiSocioeconomic status

Identifiers

PMID35174044
PMCPMC8757381

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.