ArticleAmerican journal of translational research2022
A predictive model for postoperative cognitive dysfunction in elderly patients with gastric cancer: a retrospective study.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Cognitive dysfunction in older patients undergoing non-neurosurgery in the immediate postoperative period: A systematic review.Nursing open · 2024Pooled it
- Effects of regional cerebral oxygen saturation monitoring on postoperative cognitive dysfunction in older patients: a systematic review and meta-analysis.BMC geriatrics · 2023Pooled it
- Prediction models for postoperative cognitive dysfunction in adults: a systematic review of methodological quality and clinical applicability.Frontiers in neurologyPooled it
- Applications of machine learning and natural language processing to neurocognitive outcomes in posttreatment cancer survivors: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Biochemical impact of dexmedetomidine on inflammatory and stress markers in gastric cancer surgery: A meta-analysis.Journal of medical biochemistry · 2026Article
- Current status and influencing factors of early delayed neurocognitive recovery in older adult patients after major orthopedic surgery under general anesthesia: a cohort study.Frontiers in public health · 2026Observational
- Advances in risk prediction models for cancer-related cognitive impairment.Clinical and experimental medicine · 2025Review
- Superior neuroprotective effect of ciprofol over propofol in elderly patients undergoing laparoscopic radical gastrectomy.American journal of translational research · 2025Article
- Emerging Insights into Postoperative Neurocognitive Disorders: The Role of Signaling Across the Gut-Brain Axis.Molecular neurobiology · 2024Review
- Combined use of dexmedetomidine and nalbuphine in laparoscopic radical gastrectomy for gastric cancer.World journal of gastrointestinal oncology · 2024Article
- Cognitive and Cerebrospinal Fluid Alzheimer's Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls.Anesthesiology · 2024Article
- Effects of dexmedetomidine on renal function, inflammatory markers, and cognitive functioning in elderly patients undergoing hip replacement surgery.American journal of translational research · 2024Article
- Novel Bedside Dynamic Nomograms to Predict the Probability of Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Noncardiac Surgery: A Retrospective Study.Clinical interventions in aging · 2022Article
- Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients.Frontiers in surgery · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the risk factors of postoperative cognitive dysfunction (POCD) in elderly patients with gastric cancer after radical resection and to establish a risk prediction model.
methodsA retrospective analysis of the clinicopathological data of 687 elderly patients who underwent radical gastric cancer surgery from January 2014 to January 2020 in the Third Department of Surgery, Fourth Hospital of Hebei Medical University was conducted. The degree of cognitive impairment was divided into POCD positive group (n=141, 20.52%) and POCD negative group (n=546, 79.48%). The general data of the two groups were compared. Multivariate logistic regression was used to analyze the risk factors for POCD in elderly gastric cancer patients after radical surgery. A risk prediction model was established. The receiver operating characteristic (ROC) curve was used to evaluate the effectiveness of the model.
resultsMultivariate logistic regression analysis showed that preoperative ASA classification (OR=4.674, 95% CI: 1.610~12.651, P=0.020), age (OR=3.130, 95% CI: 1.307~8.669, P=0.001), operation time (OR=2.724, 95% CI: 1.232~7.234, P=0.031), preoperative PG-SGA score (OR=4.023, 95% CI: 1.011-10.883, P=0.048), and preoperative hemoglobin (OR=4.158, 95% CI: 2.255~8.227, P=0.001) were independent risk factors for POCD. Intraoperative application of dexmedetomidine (OR=0.172, 95% CI: 0.078~0.314, P=0.002) and maintaining a deeper anesthesia state (OR=0.151, 95% CI: 0.122~0.283, P=0.018) were protective factors. The area under the ROC curve of the POCD risk prediction model for elderly gastric cancer patients after surgery was 0.820 (95% CI: 0.742-0.899) (P<0.01).
conclusionThe occurrence of postoperative POCD in elderly patients with gastric cancer is closely related to a variety of risk factors. By establishing a risk prediction model for the occurrence of POCD, high-risk patients can be effectively identified during the perioperative period, to intervene earlier.
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35173886PMC8829645W4213392579What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.