Efficacy and safety of magnetic resonance-guided focused ultrasound surgery (MRgFUS) ablation in the management of abnormal uterine bleeding due to uterine leiomyoma or adenomyosis.

Yaoqu Huang, Shouguo Zhou, Juan Wang, Zhuochao Pang

Open access · greenAbstract read

In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed, 1 pooled it

1.3field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

Reproductive outcomes after fertility-sparing interventions for symptomatic adenomyosis: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025
Pooled it
Magnetic resonance-guided focused ultrasound surgery for adenomyosis: current evidence and future directions.Frontiers in medicine · 2026
Review
Contained Power Morcellation in Laparoscopic Uterine Myoma Surgeries: A Brief Review.Healthcare (Basel, Switzerland) · 2023
Review
Precision Imaging Guidance in the Era of Precision Oncology: An Update of Imaging Tools for Interventional Procedures.Journal of clinical medicine · 2022
Review
High-intensity focused ultrasound in adenomyosis treatment: Insights on safety, efficacy, and reproductive prospects.Women's health (London, England)
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yaoqu HuangDepartment of MRI and MRgFUS, Affiliated Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Qinren Road, Chancheng District, Foshan 528000, Guangdong Province, P. R. China.

Shouguo ZhouDepartment of MRI and MRgFUS, Affiliated Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Qinren Road, Chancheng District, Foshan 528000, Guangdong Province, P. R. China.

Juan WangDepartment of MRI and MRgFUS, Affiliated Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Qinren Road, Chancheng District, Foshan 528000, Guangdong Province, P. R. China.

Zhuochao PangDepartment of Gynecology, Affiliated Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Qinren Road, Chancheng District, Foshan 528000, Guangdong Province, P. R. China.

Foshan Hospital of TCM · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the efficacy and safety of magnetic resonance-guided focused ultrasound surgery (MRgFUS) ablation for abnormal uterine bleeding (AUB) due to uterine leiomyoma or adenomyosis.

methodsIn total, thirty patients with AUB due to uterine leiomyoma (AUB-L group) or adenomyosis (AUB-A group) were treated by MRgFUS ablation. After MRgFUS ablation, the short-term clinical efficacy within one year was assessed.

resultsSixteen patients were classified into the AUB-L group and 14 patients into the AUB-A group. The average nonperfused volume (NPV) ratios of the AUB-L and AUB-A groups were 82.7% ± 13.6% and 83.3% ± 11.1%, respectively. Compared with the baseline, the lesion volumes in the AUB-L and AUB-A groups were reduced by 45.6% and 34.6%, respectively, at 3 months after MRgFUS ablation. The hemoglobin concentration was increased by 22.4% in the AUB-L group and 15.3% in the AUB-A group at 3 months posttreatment. No amenorrhea occurred during the 12-month follow-up. The duration of bleeding decreased significantly in the AUB-A group. The mean PBAC scores at 3, 6 and 12 months posttreatment were reduced by 50.8%, 48.4% and 42.8%, respectively, in the AUB-L group and by 50.9%, 53.8% and 47.9%, respectively, in the AUB-A group. Compared with the baseline, at 3, 6 and 12 months posttreatment, the HRQL score increased by 41.5%, 43.3% and 33.3%, respectively, in the AUB-L group and by 24.7%, 31.1% and 28.2%, respectively, in the AUB-A group.

conclusionMRgFUS is an effective and safe noninvasive uterine-sparing treatment modality in the management of AUB-L and AUB-A. MRgFUS can target lesion for ablation effectively, remove the factors that lead to AUB, retain a normal menstrual cycle, relieve AUB symptoms significantly and improve quality of life.

Indexed as

abnormal uterine bleedingadenomyosisleiomyomaMagnetic resonance-guided focused ultrasound surgeryuterine

Identifiers

PMID35173883

PMCPMC8829638

OpenAlexW4213392292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.