Evidence map›Paper›PMID 35173880›Full record

ArticleAmerican journal of translational research2022

Mu opioid receptor gene variant modulates subjective response to smoked cannabis.

Zoe Bourgault, Justin Matheson, Robert E Mann, Bruna Brands, Christine M Wickens, Arun K Tiwari, Clement C Zai, James Kennedy, Bernard Le Foll

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Cannabis use disorder: from neurobiology to treatment.The Journal of clinical investigation · 2024
    Review
  2. Association betweenBrain sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zoe BourgaultTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto 33 Ursula Franklin Street, Toronto, ON, Canada.
Justin MathesonTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto 33 Ursula Franklin Street, Toronto, ON, Canada.
Robert E MannInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health Toronto, Canada.
Bruna BrandsDepartment of Pharmacology and Toxicology, University of Toronto Toronto, ON, Canada.
Christine M WickensDepartment of Pharmacology and Toxicology, University of Toronto Toronto, ON, Canada.
Arun K TiwariNeurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute CAMH, Toronto, ON, Canada.
Clement C ZaiNeurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute CAMH, Toronto, ON, Canada.
James KennedyNeurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute CAMH, Toronto, ON, Canada.
Bernard Le FollTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto 33 Ursula Franklin Street, Toronto, ON, Canada.
University of Toronto · CABroad Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mu-opioid receptor (MOR) mediates the rewarding properties of many psychoactive drugs and is an important target in the treatment of addictions. Functional interactions between the opioid and endocannabinoid systems are established and have been hypothesized to contribute to the effects of cannabis. We investigated associations between three single nucleotide polymorphisms in the MOR gene

Indexed as

Cannabisgeneticsmu opioid receptorsubjective effects

Identifiers

PMID35173880
PMCPMC8829626
OpenAlexW4213393612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.