ArticleAmerican journal of translational research2022
circ_014260/miR-384/THBS1 aggravates spinal cord injury in rats by promoting neuronal apoptosis and endoplasmic reticulum stress.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Extracellular Vesicle-Based Biomarkers in Spinal Cord Injury: A State-of-the-Art Review on Diagnostic and Prognostic Advances.International journal of molecular sciences · 2026Review
- A Myelin Debris Cleaner for Spinal Cord Injury Recovery: Polycaprolactone / Cell Membrane Assembled Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mitochondrial Transplantation/Transfer: Promising Therapeutic Strategies for Spinal Cord Injury.Journal of orthopaedic translation · 2025Review
- THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia-reperfusion injury by inducing ferroptosis in endothelial cells.Journal of neuroinflammation · 2025Article
- Circ-KATNAL1 Knockdown Reduces Neuronal Apoptosis and Alleviates Spinal Cord Injury Through the miR-98-5p/PRDM5 Regulatory Axis.Molecular biotechnology · 2024Article
- Long non-coding RNA DANCR increases spinal cord neuron apoptosis and inflammation of spinal cord injury by mediating the microRNA-146a-5p/MAPK6 axis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the mechanism of circ_014260 regulating neuronal apoptosis, oxidative stress, and endoplasmic reticulum stress in rats with spinal cord injury (SCI)
methodsT9-L10 spinal cord segments of Sprague Dawley rats were subjected to compression or contusion injuries after T10 laminectomy to establish rat models of SCI, which were then divided into SCI group, si-circ group and oe-circ group according to the transfection. There was another sham operation group which received no treatment. There were 10 rats in each group. The Basso-Beattie-Bresnahan scale and HE staining were used to evaluate the changes in neuronal motor function in rats with SCI. TUNEL staining was used to determine the neuronal apoptosis. Flow cytometry was used to measure the changes in H
resultsCompared with the sham operation group or the untreated rat primary neurons (control group), increased expression of circ_014260 and THBS1 as well as decreased expression of miR-384 were observed in the spinal cord tissue from rats with SCI and in H
conclusionCirc_014260 promotes neuronal damage in rats with SCI by inhibiting miR-384 to up-regulate the expression of THBS1. Thus, circ_014260 could possibly be a new molecular target of SCI.
Indexed as
Identifiers
35173872PMC8829636W4213393543What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.