ArticleAmerican journal of translational research2022
Meningitis/meningoencephalitis caused by varicella zoster virus reactivation: a retrospective single-center case series study.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Varicella-zoster virus vasculopathy: a rare complication of Ramsay Hunt Syndrome: a literature review.Frontiers in neurology · 2025Pooled it
- Prognostic Factors and Clinical Characteristics of Varicella Zoster Virus Meningitis: Impact of Treatment Delay and Age-Related Differences in a Japanese Tertiary Hospital.Neurology international · 2026Article
- Varicella-zoster virus infection of the central nervous system: clinical features and proteomic analysis of cerebrospinal fluid.Frontiers in cellular and infection microbiology · 2026Article
- Selective Use of Magnetic Resonance Imaging for Facial Palsy in the Pediatric Emergency Department.Pediatric emergency care · 2026Observational
- Varicella-zoster virus-associated central nervous system infection in immunocompromised vs. immunocompetent herpes zoster patients: a comparative study.Frontiers in immunology · 2026Article
- Hyponatremia Due to VZV-Induced SIADH in an Older Patient: Case Report and Literature Review.Infectious disease reports · 2025Article
- Modeling Virus-Associated Central Nervous System Disease in Non-Human Primates.International journal of molecular sciences · 2025Review
- Predictive value of blood routine-derived inflammation indexes for varicella-zoster virus meningitis in patients with acute herpes zoster.Frontiers in cellular and infection microbiology · 2025Article
- Coagulation functions and factors correlated with central nervous system infection in herpes zoster patients.Frontiers in immunology · 2025Article
- Prospective Analysis of Central Nervous System Infection Risks in Varicella-Zoster Virus Reactivation Cases: A Single-Center Prospective Study of 1030 Cases.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Increase in Adult Patients with Varicella Zoster Virus-Related Central Nervous System Infections, Japan.Emerging infectious diseases · 2024Article
- Article
- "Bloomy rind sign" in varicella-zoster virus brainstem meningoencephalitis.Radiology case reports · 2024Article
- Challenges in Diagnosing Varicella-Zoster Virus Encephalitis in an Immunocompromised Patient.Cureus · 2024Article
- Immune changes and their relationship with prognosis in patients with varicella-zoster virus encephalitis/meningitis.American journal of translational research · 2023Article
- Can we forecast poor outcome in herpes simplex and varicella zoster encephalitis? A narrative review.Frontiers in neurology · 2023Review
- Factors Predictive of Varicella Zoster Virus Encephalitis/Meningitis: A Single-Center, Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent clinical studies showed that central nervous system (CNS) infection caused by varicella zoster virus (VZV) reactivation was more than previously reported. The clinical manifestations were often diverse and complex, and the outcome often varied among different patients. A systematic study is needed to provide clinical characteristics of the CNS VZV infection to help clinicians with clinical diagnosis and management. Toward that end, we retrospectively analyzed the clinical presentations, laboratory results, imaging findings, treatment and outcomes in74 patients with meningitis or meningoencephalitis caused by VZV reactivation in our center from August 2018 to December 2020. Fever, headache, cranial nerve involvement, cognitive changes, meningeal irritation, nausea, vomiting, and Ramsay-Hunt syndrome (RHS) were the most common clinical manifestations of VZV meningitis or meningoencephalitis. Brain MRI analysis showed no obvious abnormal manifestation. Compared to VZV meningoencephalitis, patients with VZV meningitis were younger (56.9±13.8 vs 66.1±8.5 years; P=0.01), and more likely to develope in winter (P=0.04), had lower cerebrospinal fluid (CSF) glucose content (3.68±0.79 vs 4.21±0.94 mmol/L, P=0.02), and a better outcome at discharge (P=0.00). The outcome at discharge was worse in male patients and when longer than 1.5 days passed between onset of the neurological symptoms to initiation of the antiviral treatment.Early intravenous antiviral treatment for VZV meningitis and meningoencephalitis is important and is expected for a good outcome.
Indexed as
Identifiers
35173869PMC8829630W4213392751What OpenQuestion holds
Registered trials
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