Deciphering the involvement of iron targets in colorectal cancer: a network biology approach.

Abdul Arif Khan, Mohd Tashfeen Ashraf, Fahad M Aldakheel, Ayca Sayi Yazgan, Rana Zaidi

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Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 60% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Abdul Arif KhanDivision of Microbiology, Indian Council of Medical Research-National AIDS Research Institute Pune, Maharashtra 411026, India.

Mohd Tashfeen AshrafSchool of Biotechnology, Gautam Buddha University Gautam Budh Nagar, Greater Noida, Uttar Pradesh 201308, India.

Fahad M AldakheelDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University Riyadh, Saudi Arabia.

Ayca Sayi YazganDepartment of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University Maslak, Istanbul 34469, Turkey.

Rana ZaidiDepartment of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard New Delhi 110062, India.

Gautam Buddha University · INIstanbul Technical University · TRJamia Hamdard · INKing Saud Medical City · SANational AIDS Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies suggested the role of heme iron, but not non-heme iron in colorectal cancer. A network and system biology-based approach was used to understand the role of heme and non-heme iron on colorectal cancer etiology. Heme and non-heme iron targets were screened in addition to CRC targets. The protein-protein interaction map of both iron targets was prepared with CRC targets. Moreover, functional enrichment analysis was performed in order to understand their role in cancer etiology. The heme iron is predicted to modulate several cancer-associated pathways. Our results indicate several targets and pathways, including IL-4/IL-13, ACE, and HIF-1 signaling, that may have an important role in heme iron-mediated CRC and must be given consideration for understanding their role in colorectal cancer.

Indexed as

cancer biologycarcinogenesiscolon cancerHemeprotein-protein interactionssignaling

Identifiers

PMID35173863

PMCPMC8829595

OpenAlexW4213392953

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.