Evidence map›Paper›PMID 35173761›Full record

ArticleFrontiers in genetics2021

Maternal Overnutrition During Gestation in Sheep Alters Autophagy Associated Pathways in Offspring Heart.

Yang Liu, Qiyue Ding, Steven J Halderson, Sebastian I Arriola Apelo, Amanda K Jones, Sambhu M Pillai, Maria L Hoffman, Sarah Reed, Kristen E Govoni, Steven A Zinn and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yang LiuDepartment of Animal and Diary Sciences, University of Wisconsin-Madison, Madison, WI, United States.
Qiyue DingDepartment of Animal and Diary Sciences, University of Wisconsin-Madison, Madison, WI, United States.
Steven J HaldersonDepartment of Animal and Diary Sciences, University of Wisconsin-Madison, Madison, WI, United States.
Sebastian I Arriola ApeloDepartment of Animal and Diary Sciences, University of Wisconsin-Madison, Madison, WI, United States.
Amanda K JonesDepartment of Animal Science, University of Connecticut, Storrs, CT, United States.
Sambhu M PillaiDepartment of Animal Science, University of Connecticut, Storrs, CT, United States.
Maria L HoffmanDepartment of Animal Science, University of Connecticut, Storrs, CT, United States.
Sarah ReedDepartment of Animal Science, University of Connecticut, Storrs, CT, United States.
Kristen E GovoniDepartment of Animal Science, University of Connecticut, Storrs, CT, United States.
Steven A ZinnDepartment of Animal Science, University of Connecticut, Storrs, CT, United States.
Wei GuoDepartment of Animal and Diary Sciences, University of Wisconsin-Madison, Madison, WI, United States.
University of Connecticut · USUniversity of Wisconsin–Madison · US

Funding

Posttranscriptional Regulation of RNA Binding Proteins in Heart FailureR01HL148733 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, WEI · 2020 to 2023
$1.5M
Maternal Obesity and Origin of Adult Offspring Cardiovascular DiseaseR03HD101870 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, WEI · 2020 to 2021
$155k
NHLBI NIH HHS R01 HL148733NICHD NIH HHS R03 HD101870
6 · The paper itself

Abstract

Poor maternal nutrition during gestation can negatively affect offspring growth, development, and health pre- and post-natally. Overfeeding during gestation or maternal obesity (MO) results in altered metabolism and imbalanced endocrine hormones in animals and humans which will have long-lasting and detrimental effects on offspring growth and health. In this study, we examined the effects of overnutrition during gestation on autophagy associated pathways in offspring heart muscles at two gestational and one early postnatal time point (

Indexed as

autophagydevelopmental programmingheart musclematernal obesitypoor maternal nutritionsheep

Identifiers

PMID35173761
PMCPMC8841792
OpenAlexW4210442089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.