Evidence map›Paper›PMID 35173685›Full record

ArticleFrontiers in endocrinology2022

Increased Expression of YAP Inhibited the Autophagy Level by Upregulating mTOR Signal in the Eutopic ESCs of Endometriosis.

Tianjiao Pei, Bin Luo, Wei Huang, Dong Liu, Yujing Li, Li Xiao, Xin Huang, Yunwei Ouyang, Huili Zhu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. [Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Article
  5. Review
  6. Review
  7. Hippo signaling in mammalian reproduction.Reproduction (Cambridge, England) · 2025
    Review
  8. Article
  9. Article
  10. Hippo-YAP signaling pathway regulates autophagy of human periodontal ligament cells under cyclic tensile stress.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2023
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tianjiao PeiDepartment of Reproductive Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.
Bin LuoDepartment of Reproductive Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.
Wei HuangDepartment of Reproductive Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.
Dong LiuKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, China.
Yujing LiDepartment of Reproductive Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.
Li XiaoDepartment of Reproductive Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.
Xin HuangDepartment of Reproductive Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.
Yunwei OuyangKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, China.
Huili ZhuDepartment of Reproductive Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We first reported that the Hippo-YAP signaling pathway plays a critical role in the pathogenesis of endometriosis (EMS). Autophagy is also related to the invasion ability of endometrial cells and is involved in the pathogenesis of EMS through multi-levels. However, the precise regulatory mechanism of YAP on autophagy in the eutopic endometrial stromal cells (ESCs) is still unclear. Primary eutopic ESCs of EMS patients (

Indexed as

EndometriosisAutophagyEndometriumFemaleHumansStromal CellsTOR Serine-Threonine KinasesMTOR protein, humanTOR Serine-Threonine Kinasesautophagydecidualizationendometriosiseutopic endometrial stromal cells (eutopic ESCs)mammalian target of rapamycin (mTOR)Yes-associated protein (YAP)

Identifiers

PMID35173685
PMCPMC8842667
OpenAlexW4210419327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.