Evidence map›Paper›PMID 35173606›Full record

ArticleFrontiers in aging neuroscience2022

Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility.

Brooke A Vaughan, Janet E Simon, Dustin R Grooms, Leatha A Clark, Nathan P Wages, Brian C Clark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brooke A VaughanOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.
Janet E SimonOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.
Dustin R GroomsOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.
Leatha A ClarkOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.
Nathan P WagesOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.
Brian C ClarkOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.

Funding

Neuronal mechanisms involved in aging and ADR01AG067758 · NIA · OHIO UNIVERSITY ATHENS · PI ARNOLD, WILLIAM DAVID, CLARK, BRIAN C · 2021 to 2025
$4.1M
NIA NIH HHS R01 AG067758
6 · The paper itself

Abstract

backgroundApproximately 35% of individuals over age 70 report difficulty with mobility. Muscle weakness has been demonstrated to be one contributor to mobility limitations in older adults. The purpose of this study was to examine the moderating effect of brain-predicted age difference (an index of biological brain age/health derived from structural neuroimaging) on the relationship between leg strength and mobility.

methodsIn community dwelling older adults (

resultsLeg strength was significantly correlated with BPAD (

conclusionThe relationship between strength and mobility appears to be influenced by brain aging, with strength serving as a possible compensation for decline in neural integrity.

Indexed as

brain agingdynapeniaphysical functionsarcopeniaweakness

Identifiers

PMID35173606
PMCPMC8841783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.