Evidence map›Paper›PMID 35173544›Full record

ArticleInternational journal of biological sciences2022

TBL1X and Flot2 form a positive feedback loop to promote metastasis in nasopharyngeal carcinoma.

Hongjuan Xu, Xuejun Yan, Hecheng Zhu, Yuanbo Kang, Weiren Luo, Jin Zhao, Kefan Zhou, Xiwu Liu, Li Ye, Quanwei Zhou and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  9. Roles of THEM4 in the Akt pathway: a double-edged sword.Journal of Zhejiang University. Science. B · 2024
    Review
  10. HDAC6-mediated deacetylation of FLOT2 maintains stability and tumorigenic function of FLOT2 in nasopharyngeal carcinoma.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  11. Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Hongjuan XuCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Xuejun YanCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Hecheng ZhuChangsha Kexin Cancer Hospital, Changsha, Hunan 410008, China.
Yuanbo KangCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Weiren LuoCancer Research Institute, Shenzhen Third People's Hospital, the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong 518112, China.
Jin ZhaoCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Kefan ZhouCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Xiwu LiuCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Li YeCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Quanwei ZhouDepartment of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Shasha LiCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Ming ZhaoChangsha Kexin Cancer Hospital, Changsha, Hunan 410008, China.
Lei WangCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Bin ZhuCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Weidong LiuCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Jianxiong LiDepartment of Radiotherapy, Chinese PLA General Hospital, Beijing 100089, China.
Xingjun JiangDepartment of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Caiping RenCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, NHC Key Laboratory of Biological Nanotechnology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis is the main cause of death in patients with nasopharyngeal carcinoma (NPC). The molecular mechanisms underlying the metastasis of NPC remain to be elucidated. TBL1X has been shown abnormally expressed in diverse cancers. However, the role and mechanism of TBL1X in NPC remain unknown. Here, we showed TBL1X expression was significantly higher in metastatic NPC tissues compared to non-metastatic tissues and significantly correlated with TNM stage and metastasis of NPC patients. In addition, NPC patients with high TBL1X expression had a poor prognosis. TBL1X interacted with TCF4 to trans-activate Flot2 expression. TBL1X promoted NPC cell migration and invasion in vitro and

Indexed as

CarcinomaNasopharyngeal NeoplasmsCell Line, TumorCell MovementFeedbackGene Expression Regulation, NeoplasticHumansNasopharyngeal CarcinomaFlotillin-2 (Flot2)metastasisNasopharyngeal carcinoma (NPC)prognosisTransducin β-like protein 1 X (TBL1X)

Identifiers

PMID35173544
PMCPMC8771836
OpenAlexW4206558547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.