ArticleDrug design, development and therapy2022
Determining the Minimum Effective Concentration of Ropivacaine in Epidural Anesthesia for Tolerable Pain in Transforaminal Percutaneous Endoscopic Lumbar Discectomy to Avoid Nerve Injury: A Double-Blind Study Using a Biased-Coin Design.
Article in Drug design, development and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 11 citations in OpenAlex.
- Comparison of the EDDrug design, development and therapy · 2026Trial
- The Optimal Effective Concentration of Spinal Anesthesia for Interlaminar Endoscopic Lumbar Discectomy: An Approach Based on the Biased Coin Design.Drug design, development and therapy · 2026Trial
- The 90% Minimum Effective Dose of Oxycodone for Thoracoscopic Lobectomy in Elderly Patients: A Double-Blind Study Using a Biased-Coin Design.Drug design, development and therapy · 2026Trial
- Topical Airway Lidocaine Spray Reduces the 95% Effective Dose of Sufentanil for Blunting Hemodynamic Response to Tracheal Intubation in Elderly Patients: A Biased-Coin Up-and-Down Sequential Allocation Trial.Drug design, development and therapy · 2026Trial
- Minimum Effective Concentration of Ropivacaine for Ultrasound-Guided RISS Block in VATS: A Biased Coin Design Approach.Drug design, development and therapy · 2025Trial
- Comparison of different concentrations of ropivacaine in epidural anesthesia for percutaneous transforaminal endoscopic discectomy: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Ropivacaine Spinal Anesthesia for IELD: Dose-Finding Pitfalls and Scoring Inconsistency [Letter].Drug design, development and therapy · 2026Article
- The 90% effective dose of remimazolam in combination with sufentanil for sedation in patients undergoing gastroscopy.Frontiers in medicine · 2026Article
- Identification of copper death-associated molecular clusters and immunological profiles for lumbar disc herniation based on the machine learning.Scientific reports · 2024Article
- Comparison of Safety and Efficacy of Anesthesia Methods in Percutaneous Endoscopic Lumbar Discectomy: A Network Meta-Analysis.Pain research & management · 2024Review
- Determining the Maximum Tolerable Concentration of Ropivacaine to Maintain Sensation of the Nerve Root in Percutaneous Endoscopic Transforaminal Lumbar Discectomy: Can Epidural Anaesthesia Achieve Pain-Tactile Separation Block to Avoid Nerve Injury?Drug design, development and therapy · 2024Article
- Spinal anesthesia for L5-S1 interlaminar endoscopic lumbar discectomy: a retrospective study.BMC musculoskeletal disorders · 2023Article
- Ultrasound-guided erector spinae plane block for awake spine surgery: A case report and review of the literature.Saudi journal of anaesthesiaArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEpidural anesthesia (EA) is the main anesthesia method for transforaminal percutaneous endoscopic lumbar discectomy (PELD). Reducing the concentration of ropivacaine can help preserve tactile sensation, allowing patients to provide timely feedback to the surgeons when a nerve root is contacted to avoid nerve injury. Therefore, a 90% effective concentration (EC
methodsThe concentration of ropivacaine for EA was varied for consecutive patients in this study using a two-stage biased-coin design (BCD) according to the response of the previous patient; the concentration used for the first patient was 0.2%. When the previous patient had a negative response (VAS score >3), the concentration used for the next one was increased by 0.015%. When the previous patient had a positive response (VAS score ≤3), the concentration used for the next one had an 89% probability of remaining the same and an 11% probability of being reduced by 0.015%. The EC
resultsA total of 58 patients were included in the study. The calculated EC
conclusionTo preserve maximum tactile sensation, the EC
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.