ArticleNature2022
Twin study reveals non-heritable immune perturbations in multiple sclerosis.
Open access · hybridAbstract readTwin Study
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 92 citations in OpenAlex.
- Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved Questions.Neurology and therapy · 2026Review
- CytoVI: deep generative modeling of antibody-based single cell data.Nature methods · 2026Article
- Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting.Nature reviews. Immunology · 2026Review
- Multikingdom microbiome-based machine learning enables multiple sclerosis diagnosis.NPJ biofilms and microbiomes · 2026Article
- Immune cell profiling reveals expanded stem cell-like memory T cells in anti-GAD65-associated neurological syndromes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- FKBP5 regulates interferon signaling leading to myeloid cell activation in multiple sclerosis.Journal of neuroinflammation · 2026Article
- Huazhuo Decoction Contributes to Immune Homeostasis and Attenuates Neuronal Inflammation and Demyelination in a Mouse Model of Multiple Sclerosis.Journal of inflammation research · 2026Article
- Dysregulation of homeostatic cytokine receptors drives prolonged T cell activation following acute SARS-CoV-2 infection in humans.Nature communications · 2025Article
- Familial multiple sclerosis is associated with accelerated progression to secondary progressive phase: a retrospective single-center cohort study.Journal of neurology · 2025Article
- Peripheral HLA-DRNeurology(R) neuroimmunology & neuroinflammation · 2025Article
- Phenotyping Healthcare Use 2-3 Decades Before the First Multiple Sclerosis Demyelinating Event.Annals of clinical and translational neurology · 2025Article
- Atopy-related immune profiles are subject to genetic influence as evaluated using school-aged twin pairs.Science advances · 2025Article
- Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Barancik award lecture: Multi-disciplinary research will be the key to stop, restore, and end MS.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Multiple sclerosis and infection: history, EBV, and the search for mechanism.Microbiology and molecular biology reviews : MMBR · 2025Review
- Epstein-Barr virus infection promotes T cell dysregulation in a humanized mouse model of multiple sclerosis.Science advances · 2025Article
- Review
- Immunological microenvironment and targeted therapeutics in multiple sclerosis: new insights in crosstalk between immune niches and CNS.Frontiers in immunology · 2025Review
- Remyelinating Drugs at a Crossroad: How to Improve Clinical Efficacy and Drug Screenings.Cells · 2024Review
- An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 4 countries.
Florian Ingelfinger *Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Lisa Ann Gerdes *Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.
Vladyslav KavakaInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.
Sinduya KrishnarajahInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Ekaterina FriebelInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Edoardo GalliInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-9760-2643
Pascale ZwickyInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-0419-2153
Reinhard FurrerDepartment of Mathematics, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-6319-2332
Christian PeukertDepartment of Strategy, Globalization and Society, University of Lausanne, Lausanne, Switzerland.
Charles-Antoine DutertreGustave Roussy Cancer Campus, Villejuif, France.
Klara Magdalena EglseerInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.
Florent GinhouxSingapore Immunology Network, A*STAR, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2857-7755
Andrea Flierl-HechtInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.
Tania KümpfelInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.
Donatella De FeoInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Bettina SchreinerInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Sarah MundtInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Martin KerschensteinerInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-4898-9383
Reinhard HohlfeldInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.
Eduardo BeltránInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-7266-4098
Burkhard BecherInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland. becher@immunology.uzh.ch.ORCID http://orcid.org/0000-0002-1541-7867
University of Zurich · CHLMU Klinikum · DEAgency for Science, Technology and Research · SGInserm · FRUniversity of Lausanne · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system underpinned by partially understood genetic risk factors and environmental triggers and their undefined interactions
Indexed as
Multiple SclerosisGenetic Predisposition to DiseaseHumansInterleukin-2OX40 LigandTwins, DizygoticTwins, MonozygoticIL2 protein, humanInterleukin-2OX40 LigandTNFSF4 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.