Evidence map›Paper›PMID 35173278›Full record

Trial reportInternational journal of obesity (2005)2022

Combined training increases thermogenic fat activity in patients with overweight and type 2 diabetes.

Ivan Luiz Padilha Bonfante, Milena Monfort-Pires, Renata Garbellini Duft, Keryma Chaves da Silva Mateus, José Carlos de Lima Júnior, Joice Cristina Dos Santos Trombeta, Enrico Antonio Rautenberg Finardi, Diego Trevisan Brunelli, Joseane Morari, Jéssica Aparecida Barbosa de Lima and 6 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  20. New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Ivan Luiz Padilha BonfanteLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil. ivanlpb@hotmail.com.ORCID http://orcid.org/0000-0001-6278-4611
Milena Monfort-Pires *Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, SP, 13084-970, Brazil.
Renata Garbellini Duft *Laboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil.ORCID http://orcid.org/0000-0003-0031-6171
Keryma Chaves da Silva Mateus *Laboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil.
José Carlos de Lima Júnior *Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, SP, 13084-970, Brazil.ORCID http://orcid.org/0000-0001-9430-4475
Joice Cristina Dos Santos TrombetaLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil.
Enrico Antonio Rautenberg FinardiLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil.
Diego Trevisan BrunelliLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil.
Joseane MorariLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, SP, 13084-970, Brazil.
Jéssica Aparecida Barbosa de LimaLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil.
Maria Luisa BellottoLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil.
Thiago Matos Ferreira de AraújoLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, SP, 13084-970, Brazil.
Celso Darío RamosDepartment of Radiology, University of Campinas, Campinas, SP, 13084-970, Brazil.ORCID http://orcid.org/0000-0002-1312-1026
Mara Patricia Traina Chacon-MikahilLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil.
Licio Augusto VellosoLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, SP, 13084-970, Brazil.ORCID http://orcid.org/0000-0002-4806-7218
Cláudia Regina CavaglieriLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, 13083-970, Brazil. cavaglieri@fef.unicamp.br.
Universidade Estadual de Campinas (UNICAMP) · BRFederal Institute of São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise is an important strategy in the management of diabetes. Experimental studies have shown that exercise acts, at least in part, by inducing the production of myokines that improve metabolic control and activate brown/beige adipose tissue depots. Combined training (CT) is recommended by the major diabetes guidelines due to its metabolic and cardiovascular benefits, however, its impact on brown/beige adipose tissue activities has never been tested in humans with overweight and type 2 diabetes (T2D). Here, we evaluated the effects of 16-week combined training (CT) program on brown adipose tissue activity; browning and autophagy markers, and serum pro-thermogenic/inflammatory inducers in patients with overweight and T2D.

methodsThirty-four patients with overweight and T2D were assigned to either a control group (CG) or a combined training group (CTG) in a randomized and controlled study. Functional/fitness parameters, anthropometry/body composition parameters, blood hormone/biochemical parameters, thermogenic/autophagic gene expression in subcutaneous adipose tissue were evaluated before and at the end of the intervention. In addition, cold-induced 18-Fluoroxyglucose Positron Emission Computed Tomography (18

resultsCT increased cervical/supraclavicular brown adipose tissue (BAT) thermogenic activity (p = 0.03) as well as in perirenal adipose tissue (p = 0.02). In addition, CT increased the expression of genes related to thermogenic profile (TMEM26: + 95%, p = 0.04; and EPSTI1: + 26%, p = 0.03) and decreased autophagic genes (ULK1: -15%, p = 0.04; LC3: -5%, p = 0.02; and ATG4: -22%, p < 0.001) in subcutaneous adipose tissue. There were positive correlations between Δ% BAT activity with Δ% of post training energy expenditure cold exposure, HDL-c, IL4, adiponectin, irisin, meteorin-like, and TMEM26 and ZIC1 genes, besides negative correlations with LDL-c, total cholesterol and C-reactive protein.

conclusionThis is the first evidence of the beneficial actions of CT on adipose tissue thermogenic activity in humans, and it adds important support for the recommendation of CT as a strategy in the management of diabetes.

Indexed as

Diabetes Mellitus, Type 2OverweightAdipose Tissue, BrownFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyThermogenesisFluorodeoxyglucose F18

Identifiers

PMID35173278
OpenAlexW4213003968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.