Evidence map›Paper›PMID 35173210›Full record

ArticleScientific reports2022

Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models.

Paula Zwicker, Johannes Schleusener, Silke B Lohan, Loris Busch, Claudia Sicher, Sven Einfeldt, Michael Kneissl, Anja A Kühl, Cornelia M Keck, Christian Witzel and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Effectiveness of UmoniumBMC infectious diseases · 2024
    Article
  6. Article
  7. Article
  8. Sensitivity Analysis ofPathogens & immunity · 2024
    Article
  9. Article
  10. Article
  11. Phenotypic Variation in ClinicalMicroorganisms · 2023
    Article
  12. Far-UVC Radiation for Disinfecting Hands or Gloves?Pathogens (Basel, Switzerland) · 2023
    Article
  13. Article
  14. Sensitivity of influenza virus to ultraviolet irradiation.GMS hygiene and infection control · 2022
    Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Paula Zwicker *Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475, Greifswald, Germany.
Johannes Schleusener *Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Silke B LohanCenter of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Loris BuschCenter of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Claudia SicherInstitute of Hygiene and Environmental Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475, Greifswald, Germany.
Sven EinfeldtFerdinand-Braun-Institut gGmbH, Leibniz-Institut Für Höchstfrequenztechnik, Gustav-Kirchhoff-Str. 4, 12489, Berlin, Germany.
Michael KneisslFerdinand-Braun-Institut gGmbH, Leibniz-Institut Für Höchstfrequenztechnik, Gustav-Kirchhoff-Str. 4, 12489, Berlin, Germany.
Anja A KühliPATH.Berlin-Immunopathology for Experimental Models, Core Facility of the Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Cornelia M KeckDepartment of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35032, Marburg, Germany.
Christian WitzelDivision of Plastic and Reconstructive Surgery, Department of Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Axel KramerInstitute of Hygiene and Environmental Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475, Greifswald, Germany.
Martina C MeinkeCenter of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany. martina.meinke@charite.de.
Humboldt-Universität zu Berlin · DEUniversitätsmedizin Greifswald · DEFerdinand-Braun-Institut · DEFreie Universität Berlin · DECharité - Universitätsmedizin Berlin · DEPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A newly developed UVC LED source with an emission wavelength of 233 nm was proved on bactericidal efficacy and skin tolerability. The bactericidal efficacy was qualitatively analysed using blood agar test. Subsequently, quantitative analyses were performed on germ carrier tests using the MRSA strain DSM11822, the MSSA strain DSM799, S. epidermidis DSM1798 with various soil loads. Additionally, the compatibility of the germicidal radiation doses on excised human skin and reconstructed human epidermis was proved. Cell viability, DNA damage and production of radicals were assessed in comparison to typical UVC radiation from discharge lamps (222 nm, 254 nm) and UVB (280-380 nm) radiation for clinical assessment. At a dose of 40 mJ/cm

Indexed as

Cell SurvivalDNA DamageDose-Response Relationship, RadiationHumansMethicillin-Resistant Staphylococcus aureusRadiation DosageSafetySkinStaphylococcus epidermidisUltraviolet Rays

Identifiers

PMID35173210
PMCPMC8850561
OpenAlexW4213372589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.