ArticleScientific reports2022
Glucocorticoids coordinate changes in gut microbiome composition in wild North American red squirrels.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Gut microbiota-mediated modulation of circadian rhythms: Physiological and molecular impacts of dietary composition and feeding time.Journal of food and drug analysis · 2026Review
- Article
- Mental health and gut-brain crosstalk: implications for depression and Alzheimer's disease.Neuroscience applied · 2026Review
- Article
- Indirect Environmental Effects on the Gut-Brain Axis in a Wild Mammal.Molecular ecology · 2025Article
- Social Microbial Transmission in a Solitary Mammal.Ecology letters · 2025Article
- Lactobacillus fermentum ATCC 9338 Supplementation Prevents Depressive-Like Behaviors Through Glucocorticoid Receptor and N-Methyl-D-aspartate2b in Chronic Unpredictable Mild Stress Mouse Model.Molecular neurobiology · 2025Article
- I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms.The FEBS journal · 2025Review
- Population Dynamics and the Microbiome in a Wild Boreal Mammal: The Snowshoe Hare Cycle and Impacts of Diet, Season and Predation Risk.Molecular ecology · 2025Article
- Gut microbiota and metabolic signatures of anxiety in ulcerative colitis: a cross-sectional study.Therapeutic advances in gastroenterology · 2025Article
- Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment.Open medicine (Warsaw, Poland) · 2025Article
- Temporal patterns of gut microbiota in lemurs (Eulemur rubriventer) living in intact and disturbed habitats in a novel sample type.American journal of primatology · 2025Article
- Microbial DNA extraction method for avian feces and preen oil from diverse species.Ecology and evolution · 2024Article
- Social network dynamics, infant loss, and gut microbiota composition in female Colobus vellerosus during time periods with alpha male challenges.Primates; journal of primatology · 2024Article
- Tolerance to environmental pollution in the freshwater crustacean Asellus aquaticus: A role for the microbiome.Environmental microbiology reports · 2024Article
- Consistent spatial patterns in microbial taxa of red squirrel gut microbiomes.Environmental microbiology reports · 2024Article
- Effect of diet supplemented with functional amino acids and polyphenols on gut health in broilers subjected to a corticosterone-induced stress.Scientific reports · 2024Article
- Host-gut microbiota interactions during pregnancy.Evolution, medicine, and public health · 2024Review
- The gut microbiota-immune-brain axis in a wild vertebrate: dynamic interactions and health impacts.Frontiers in microbiology · 2024Article
- Immune-mediated hematological disease in dogs is associated with alterations of the fecal microbiota: a pilot study.Animal microbiome · 2023Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome impacts host health and fitness, in part through the diversification of gut metabolic function and pathogen protection. Elevations in glucocorticoids (GCs) appear to reduce gut microbiome diversity in experimental studies, suggesting that a loss of microbial diversity may be a negative consequence of increased GCs. However, given that ecological factors like food availability and population density may independently influence both GCs and microbial diversity, understanding how these factors structure the GC-microbiome relationship is crucial to interpreting its significance in wild populations. Here, we used an ecological framework to investigate the relationship between GCs and gut microbiome diversity in wild North American red squirrels (Tamiasciurus hudsonicus). As expected, higher GCs predicted lower gut microbiome diversity and an increase in metabolic taxa. Surprisingly, but in line with prior empirical studies on wild animals, gastrointestinal pathogens decreased as GCs increased. Both dietary heterogeneity and an upcoming food pulse exhibited direct effects on gut microbiome diversity, whereas conspecific density and reproductive activity impacted diversity indirectly via changes in host GCs. Our results provide evidence of a gut-brain axis in wild red squirrels and highlight the importance of situating the GC-gut microbiome relationship within an ecological framework.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.