ArticleScientific reports2022
Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- An electric field modeling study with meta-analysis to understand the antidepressant effects of transcranial direct current stimulation (tDCS).Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Enhancement of the left frontoparietal network through real-time functional magnetic resonance imaging functional connectivity-informed neurofeedback and its impact on working memory in schizophrenia: A pilot study.Psychiatry and clinical neurosciences · 2025Trial
- Paving the way for precision treatment of psychiatric symptoms with functional connectivity neurofeedback.Translational psychiatry · 2026Article
- Severity-dependent fronto-cingulate network compensation of immune-dependent caudate-insula dysconnectivity in bipolar II depression.Research square · 2026Article
- Global and item-level MADRS differences between melancholic and unspecified depressive symptoms under rTMS: an exploratory analysis.Frontiers in psychiatry · 2026Article
- Article
- Cerebral Blood Flow and Blood-Brain Barrier Water Exchange in Major Depressive Disorder: Evidence from Diffusion-Prepared Arterial Spin Labelling MRI.Brain sciences · 2025Article
- Increased insular functional connectivity during repetitive negative thinking in major depression and healthy volunteers.Psychological medicine · 2025Article
- Effectiveness of fMRI-based Neurofeedback Therapy on Depression: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Review
- Structural alterations as a predictor of depression - a 7-Tesla MRI-based multidimensional approach.Molecular psychiatry · 2025Article
- Towards an expanded neurocognitive account of ketamine's rapid antidepressant effects.The international journal of neuropsychopharmacology · 2025Review
- Non-invasive brain stimulation for suicidal ideation: a systematic review and metanalysis of the current literature.AIMS neuroscience · 2025Review
- Negative rumination in depression subtypes with melancholic features and anxious distress.Frontiers in psychology · 2025Article
- Neural divergence between individuals with and without minor depression during dynamic emotion processing: a movie-fMRI Study.Social cognitive and affective neuroscience · 2024Article
- Amygdala self-neuromodulation capacity as a window for process-related network recruitment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Functional Network Connectivity for Components of Depression-Related Psychological Fragility.Brain sciences · 2024Article
- The Effect of Continuous Theta Burst Stimulation over the Right Dorsolateral Prefrontal Cortex on Cognitive Function and Emotional Regulation in Patients with Cerebral Small Vessel Disease.Brain sciences · 2023Article
- Targeted neurorehabilitation strategies in post-stroke aphasia.Restorative neurology and neuroscience · 2023Review
- Facing emotions: real-time fMRI-based neurofeedback using dynamic emotional faces to modulate amygdala activity.Frontiers in neuroscience · 2023Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depressive disorders contribute heavily to global disease burden; This is possibly because patients are often treated homogeneously, despite having heterogeneous symptoms with differing underlying neural mechanisms. A novel treatment that can directly influence the neural circuit relevant to an individual patient's subset of symptoms might more precisely and thus effectively aid in the alleviation of their specific symptoms. We tested this hypothesis in a proof-of-concept study using fMRI functional connectivity neurofeedback. We targeted connectivity between the left dorsolateral prefrontal cortex/middle frontal gyrus and the left precuneus/posterior cingulate cortex, because this connection has been well-established as relating to a specific subset of depressive symptoms. Specifically, this connectivity has been shown in a data-driven manner to be less anticorrelated in patients with melancholic depression than in healthy controls. Furthermore, a posterior cingulate dominant state-which results in a loss of this anticorrelation-is expected to specifically relate to an increase in rumination symptoms such as brooding. In line with predictions, we found that, with neurofeedback training, the more a participant normalized this connectivity (restored the anticorrelation), the more related (depressive and brooding symptoms), but not unrelated (trait anxiety), symptoms were reduced. Because these results look promising, this paradigm next needs to be examined with a greater sample size and with better controls. Nonetheless, here we provide preliminary evidence for a correlation between the normalization of a neural network and a reduction in related symptoms. Showing their reproducibility, these results were found in two experiments that took place several years apart by different experimenters. Indicative of its potential clinical utility, effects of this treatment remained one-two months later.Clinical trial registration: Both experiments reported here were registered clinical trials (UMIN000015249, jRCTs052180169).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.