ArticleNeurology2022
Cognitive Outcome 1 Year After Mild Traumatic Brain Injury: Results From the TRACK-TBI Study.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06927063 (Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
11.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Research on the Potential Biomarkers of Mild Traumatic Brain Injury: a Systematic Review and Bibliometric Analysis.Molecular neurobiology · 2023Pooled it
- Feasibility of Using a Mobile App Supported Executive Function Intervention in Military Service Members and Veterans with mTBI and Co-Occurring Psychological Conditions.International journal of environmental research and public health · 2023Trial
- Role of Polygenic Risk Scores in Predicting Cognitive Functioning after Mild Traumatic Brain Injury: A TRACK-TBI Study.Journal of neurotrauma · 2026Article
- Long-Term Mortality and Quality of Life Among Adults With Mild Traumatic Brain Injury.JAMA network open · 2026Article
- Plasma Biomarkers, Brain Volume, and Cognitive Performance in Service Members and Veterans With mTBI: A LIMBIC-CENC Study.JAMA network open · 2026Article
- The Use of Digital Neurocognitive Assessments to Assess Traumatic Brain Injury and Dementia in Older Trauma Patients: An Emergency Department Feasibility Study.Diagnostics (Basel, Switzerland) · 2026Article
- Brain age gap as a diffusion MRI-based marker of traumatic brain injury-related brain changes and associated outcomes.Brain communications · 2026Article
- Article
- MSC-Exosomes alleviate cognitive impairment after mild traumatic brain injury by inhibiting ferroptosis via PI3K/AKT/mTOR-mediated upregulation of GPX4.Functional & integrative genomics · 2025Article
- Vascular Risk Factors and 1-Year Cognitive Change Among Individuals With Traumatic Brain Injury.JAMA network open · 2025Article
- Functional Connectivity Patterns Following Mild Traumatic Brain Injury and the Association With Longitudinal Cognitive Function.Human brain mapping · 2025Article
- Article
- Cognitive Symptoms Are Not Associated with Cognitive Performance in Post-Acute mTBI.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Screening and outcomes of co-occurring traumatic brain injury among people with spinal cord injury: a scoping review.Journal of rehabilitation medicine · 2025Article
- Recovery from Mild Traumatic Brain Injury in the Nonathletic Population: A Systematic Review.Neurotrauma reports · 2025Review
- Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury.Brain communications · 2025Review
- Individualized mouse brain network models produce asymmetric patterns of functional connectivity after simulated traumatic injury.Network neuroscience (Cambridge, Mass.) · 2025Article
- Machine Learning Models for Predicting Abnormal Brain CT Scan Findings in Mild Traumatic Brain Injury Patients.Archives of academic emergency medicine · 2025Article
- EFFECTS OF HIGHER- AND LOWER-INTENSITY EXERCISE ON FITNESS, COGNITION, MOTOR FUNCTION, AND QUALITY OF LIFE IN ADULTS WITH TRAUMATIC BRAIN INJURY.Journal of rehabilitation medicine. Clinical communications · 2025Article
- Traumatic brain injury and cognitive change over 30 years among community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Andrea L C SchneiderFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
J Russell HuieFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
W John BoscardinFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Lindsay NelsonFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Jason K BarberFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Kristine YaffeFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Ramon Diaz-ArrastiaFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Adam R FergusonFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Joel KramerFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Sonia JainFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Nancy TemkinFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Esther YuhFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.
Geoffrey T ManleyFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla.ORCID 0000-0002-0926-3128
Raquel C GardnerFrom the Department of Neurology (A.L.C.S., R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Departments of Neurosurgery (J.R.H., A.R.F., G.T.M.), Epidemiology and Biostatistics (W.J.B., K.Y.), Neurology (K.Y., J.K., R.C.G.), Psychiatry (K.Y.), and Radiology and Biomedical Imaging (E.Y.), University of California San Francisco; Department of Neurosurgery (L.N.), Medical College of Wisconsin, Madison; Departments of Neurological Surgery (J.K.B., N.T.) and Biostatistics (N.T.), University of Washington, Seattle; and Biostatistics Research Center (S.J.), Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla. raquel.gardner@ucsf.edu.
TRACK-TBI Investigators
University of Washington · USUniversity of Pennsylvania · US
Funding
Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1MTransforming Traumatic Brain Injury Research and Clinical CareRC2NS069409 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANLEY, GEOFFREY T · 2009 to 2011
$4.3MNINDS NIH HHS RC2 NS069409NINDS NIH HHS U01 NS086090
Abstract
BACKGROUND AND
objectivesThe objectives of this study were to develop and establish concurrent validity of a clinically relevant definition of poor cognitive outcome 1 year after mild traumatic brain injury (mTBI), to compare baseline characteristics across cognitive outcome groups, and to determine whether poor 1-year cognitive outcome can be predicted by routinely available baseline clinical variables.
methodsProspective cohort study included 656 participants ≥17 years of age presenting to level 1 trauma centers within 24 hours of mTBI (Glasgow Coma Scale score 13-15) and 156 demographically similar healthy controls enrolled in the Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) study. Poor 1-year cognitive outcome was defined as cognitive impairment (below the ninth percentile of normative data on ≥2 cognitive tests), cognitive decline (change score [1-year score minus best 2-week or 6-month score] exceeding the 90% reliable change index on ≥2 cognitive tests), or both. Associations of poor 1-year cognitive outcome with 1-year neurobehavioral outcomes were performed to establish concurrent validity. Baseline characteristics were compared across cognitive outcome groups, and backward elimination logistic regression was used to build a prediction model.
resultsMean age of participants with mTBI was 40.2 years; 36.6% were female; 76.6% were White. Poor 1-year cognitive outcome was associated with worse 1-year functional outcome, more neurobehavioral symptoms, greater psychological distress, and lower satisfaction with life (all DISCUSSION: Poor 1-year cognitive outcome is common, affecting 13.5% of patients with mTBI vs 4.5% of controls. These results highlight the need for better understanding of mechanisms underlying poor cognitive outcome after mTBI to inform interventions to optimize cognitive recovery.
Indexed as
Brain ConcussionBrain Injuries, TraumaticCognitive DysfunctionAdultCognitionEducational StatusFemaleGlasgow Coma ScaleHumansProspective Studies
Identifiers
What OpenQuestion holds
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Registered trials
NCT06927063ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.