ArticleProceedings of the National Academy of Sciences of the United States of America2022
Intragenic suppressors unravel the role of the SCREAM ACT-like domain for bHLH partner selectivity in stomatal development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- Dissecting the Cell-Type-Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar-Dependent Involvement of Brassinosteroid Signalling.Plant biotechnology journal · 2026Article
- Genetic encoding of climate-responsive stomatal developmental plasticity in tomato.bioRxiv : the preprint server for biology · 2026Article
- Article
- Multifaceted roles of SCRM/ICE1 in stomatal development, cold stress and beyond.Frontiers in plant science · 2026Review
- SPEECHLESS duplication in grasses expands potential for environmental regulation of stomatal development.bioRxiv : the preprint server for biology · 2025Article
- MYB74 transcription factor guides de novo specification of epidermal cells in the abscission zone of Arabidopsis.Nature plants · 2025Article
- Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain.Nature communications · 2024Article
- Molecular Mechanisms for Regulating Stomatal Formation across Diverse Plant Species.International journal of molecular sciences · 2024Review
- Article
- Evolution and diversification of the ACT-like domain associated with plant basic helix-loop-helix transcription factors.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Expanded roles and divergent regulation of FAMA in Brachypodium and Arabidopsis stomatal development.The Plant cell · 2023Article
- Stomatal regulators are co-opted for seta development in the astomatous liverwort Marchantia polymorpha.Nature plants · 2023Article
- Genome-wide identification, characterization, and validation of the bHLH transcription factors in grass pea.Frontiers in genetics · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Multicellular organisms develop specialized cell types to achieve complex functions of tissues and organs. The basic helix-loop-helix (bHLH) proteins act as master regulatory transcription factors of such specialized cell types. Plant stomata are cellular valves in the aerial epidermis for efficient gas exchange and water control. Stomatal differentiation is governed by sequential actions of three lineage-specific bHLH proteins, SPEECHLESS (SPCH), MUTE, and FAMA, specifying initiation and proliferation, commitment, and terminal differentiation, respectively. A broadly expressed bHLH, SCREAM (SCRM), heterodimerizes with SPCH/MUTE/FAMA and drives stomatal differentiation via switching its partners. Yet nothing is known about its heterodimerization properties or partner preference. Here, we report the role of the SCRM C-terminal ACT-like (ACTL) domain for heterodimerization selectivity. Our intragenic suppressor screen of a dominant
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