ArticleBMJ open respiratory research2022
Reference equations for pulmonary diffusing capacity using segmented regression show similar predictive accuracy as GAMLSS models.
Article in BMJ open respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Enhanced detection of patients with previous COVID-19: superiority of the double diffusion technique.BMJ open respiratory research · 2025Pooled it
- The Role of DLNO in the Functional Assessment of Patients with Idiopathic Pulmonary Fibrosis.Medicina (Kaunas, Lithuania) · 2026Observational
- Pulmonary diffusing capacity for nitric oxide in disease: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2026Article
- Emphysema Detection in Smokers: Diffusing Capacity for Nitric Oxide Beats Diffusing Capacity of Carbon Monoxide-Based Models.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Pulmonary diffusing capacity and dyspnoea following COVID-19: Insights from multicentre datasets.Data in brief · 2025Article
- Mexican Hispanics show significant improvement in lung function approximately 1 year after having severe COVID-19.Experimental physiology · 2024Observational
- A refined spirometry dataset for comparing segmented (piecewise) linear models to that of GAMLSS.Data in brief · 2024Article
- Changes in spirometry and pulmonary diffusing capacity in Mexican Hispanics approximately one year after having severe COVID-19: A dataset.Data in brief · 2024Article
- Reference equations for DLNO and DLCO in Mexican Hispanics: influence of altitude and race.BMJ open respiratory research · 2024Article
- Gas exchange abnormalities in Long COVID are driven by the alteration of the vascular component.Multidisciplinary respiratory medicine · 2024Article
- Two is better than one: the double diffusion technique in classifying heart failure.ERJ open research · 2024Article
- Reference equations using segmented regressions for impulse oscillometry in healthy subjects aged 2.7-90 years.ERJ open research · 2023Article
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2 authors.
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Abstract
purposeTo determine whether generalised additive models of location, scale and shape (GAMLSS) developed for pulmonary diffusing capacity are superior to segmented (piecewise) regression models, and to update reference equations for pulmonary diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO), which may be affected by the equipment used for its measurement.
methodsData were pooled from five studies that developed reference equations for DLCO and DLNO (n=530 F/546 M; 5-95 years old, body mass index 12.4-39.0 kg/m
resultsIn males, GAMLSS models were 7% worse to 3% better compared to segmented regression for DLCO and DLNO. In females, GAMLSS models were 2% worse to 5% better compared to segmented linear regression for DLCO and DLNO. The Hyp'Air Compact measured DLNO and alveolar volume (VA) that was approximately 16-20 mL/min/mm Hg and 0.2-0.4 L higher, respectively, compared to the Jaeger MasterScreen Pro. The measured DLCO was similar between devices after controlling for altitude.
conclusionsFor the development of pulmonary function reference equations, we propose that segmented linear regression can be used instead of GAMLSS due to its simplicity, especially when the predictive accuracy is similar between the two models, overall.
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