ArticleMicrobiome2022
Integrated meta-omics reveals new ruminal microbial features associated with feed efficiency in dairy cattle.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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Who cites it
119 citing papers in PubMed, 186 citations in OpenAlex.
- Pan-genomics and multi-omics for deciphering genetic variation and accelerating genetic improvement in ruminant livestock.Functional & integrative genomics · 2026Review
- Phosphorus alleviates age-associated osteoporosis in laying hens by reshaping bone metabolism and modulating cecal microbial communities.Poultry science · 2026Article
- Effects ofAnimals : an open access journal from MDPI · 2026Article
- Article
- Evaluation of Growth and Performance Traits in Limousin Weaned Bull Calves Using K-Means Clustering.Animals : an open access journal from MDPI · 2026Article
- Fermented feed-rumen microbiota axis mediates goat kid growth via microbial amino acid synthesis and ruminal epithelial energy metabolism.NPJ biofilms and microbiomes · 2026Article
- Multi-omics analysis of soy isoflavone-induced responses in rumen fermentation, endocrine status and milk production in cows with varying milk yields.Journal of animal science and biotechnology · 2026Article
- Phytosterols improve feed efficiency in yaks by enriching rumen Succiniclasticum.Animal microbiome · 2026Article
- Rumen-Plasma-Milk Metabolomics Profiling Revealed Metabolic Alterations Associated with Milk Fat Synthesis in Chinese Holstein Cows.Animals : an open access journal from MDPI · 2026Article
- Fecal Microbial Community Characteristics of Oula and Hu Sheep and Their Correlation with Semen Quality.Animals : an open access journal from MDPI · 2026Article
- Intestinal Microbiota Mediates the Beneficial Effects of γ-Polyglutamic Acid on Calcium Homeostasis and Bone Properties in Lambs.International journal of molecular sciences · 2026Article
- Physiological and Intestinal Microbiota Analyses Offer Insights into the Analysis of Differential Residual Feed Intake in Jian Carp (Animals : an open access journal from MDPI · 2026Article
- Association of the residual feed intake (RFI) with the rumen microbiota composition and metabolism in Dorper-Hu crossbred lambs.BMC microbiology · 2026Article
- The developmental trajectory and maturation of the Hulunbuir sheep (Ovis aries) microbiome.Animal microbiome · 2026Article
- Integrative analysis of rumen microbiota and host multi-organ interactions underlying feed conversion efficiency in Hu sheep.Journal of animal science and biotechnology · 2026Article
- Supplementation of Rosemary Extract Improves Lactation Performance and Rumen Function in Dairy Buffaloes Under Hot Weather.Animals : an open access journal from MDPI · 2026Article
- The impact of rumen and hindgut microbiomes on the persistent productivity of long-lived dairy cows.Microbiome · 2026Article
- Coated trace minerals improved carcass characteristics and meat quality in growing sheep in association with enhanced antioxidant status and shifts in the rumen microbiota.Frontiers in microbiology · 2026Article
- Metatranscriptomics reveals the horse gut RNA virome and a viral sharing network with human and domestic animals.Frontiers in veterinary science · 2026Article
- Redefining feed efficiency through the livestock gut microbiome.Frontiers in physiology · 2026Article
59 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs the global population continues to grow, competition for resources between humans and livestock has been intensifying. Increasing milk protein production and improving feed efficiency are becoming increasingly important to meet the demand for high-quality dairy protein. In a previous study, we found that milk protein yield in dairy cows was associated with the rumen microbiome. The objective of this study was to elucidate the potential microbial features that underpins feed efficiency in dairy cows using metagenomics, metatranscriptomics, and metabolomics.
resultsComparison of metagenomic and metatranscriptomic data revealed that the latter was a better approach to uncover the associations between rumen microbial functions and host performance. Co-occurrence network analysis of the rumen microbiome revealed differential microbial interaction patterns between the animals with different feed efficiency, with high-efficiency animals having more and stronger associations than low-efficiency animals. In the rumen of high-efficiency animals, Selenomonas and members of the Succinivibrionaceae family positively interacted with each other, functioning as keystone members due to their essential ecological functions and active carbohydrate metabolic functions. At the metabolic level, analysis using random forest machine learning suggested that six ruminal metabolites (all derived from carbohydrates) could be used as metabolic markers that can potentially differentiate efficient and inefficient microbiomes, with an accuracy of prediction of 95.06%.
conclusionsThe results of the current study provided new insights into the new ruminal microbial features associated with feed efficiency in dairy cows, which may improve the ability to select animals for better performance in the dairy industry. The fundamental knowledge will also inform future interventions to improve feed efficiency in dairy cows. Video Abstract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.