Evidence map›Paper›PMID 35172828›Full record

SynthesisHealth and quality of life outcomes2022

Health-related quality of life in individuals with genital herpes: a systematic review.

Angela Devine, Xiuqin Xiong, Sami Lynne Gottlieb, Maeve Britto de Mello, Christopher K Fairley, Jason J Ong

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Health and quality of life outcomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angela Devine *Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Xiuqin Xiong *Centre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.
Sami Lynne GottliebGlobal HIV, Hepatitis and STI Programmes, World Health Organization, Geneva, Switzerland.
Maeve Britto de MelloGlobal HIV, Hepatitis and STI Programmes, World Health Organization, Geneva, Switzerland.
Christopher K FairleyCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Jason J OngCentre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia. Jason.ong@monash.edu.ORCID http://orcid.org/0000-0001-5784-7403

Funding

China Scholarship Council 201906010310National Health and Medical Research Council 1172900National Health and Medical Research Council 1193955National Institute of Allergy and Infectious Diseases HQUCN2017628World Health Organization 001
6 · The paper itself

Abstract

backgroundThere is a significant global burden of herpes simplex virus (HSV) related genital ulcer disease yet little is known about its impact on quality of life. This systematic review aimed to identify studies that quantitatively evaluated the effect of genital herpes on various aspects of health-related quality of life.

methodsSix databases were searched (MEDLINE, EMBASE, NHS Economic Evaluation Database, Health Technology Assessment, Database of Abstracts of Reviews of Effects, Web of Science Core Collection) for primary quality of life and economic evaluations of genital herpes from January 1, 2000 to January 7, 2021. Qualitative studies or those without primary data were excluded. Two authors independently extracted data from the publications. The study's registration number with PROSPERO was CRD42021239410.

findingsWe identified 26 relevant publications: 19 presented primary quality of life data, and seven were economic evaluations. The primary studies presented a range of condition-specific tools for describing the quality of life in individuals with genital herpes, but only one study used a direct valuation that could be used to generate utility weights. All economic evaluations of HSV infection were from high-income country settings. Most (6 of 7) focused on neonatal HSV infection with utilities adopted from studies prior to 2000.

interpretationThe extant literature on genital herpes-related quality of life is limited and requires updating. We recommend future studies be conducted in geographic- and population- diverse settings, and use preference-based condition-specific or generic-instruments to better inform economic modelling.

Indexed as

Herpes GenitalisHerpes SimplexPregnancy Complications, InfectiousCost-Benefit AnalysisFemaleHumansInfant, NewbornPregnancyQuality of LifeGenital herpesHerpes simplex virusQuality of lifeSystematic review

Identifiers

PMID35172828
PMCPMC8848826

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.