ArticleBMC biology2022
Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti.
Article in BMC biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Gustatory function of Aedes aegypti opsins and TRPA1 in avoiding a natural insect repellent.Current biology : CB · 2026Article
- Herring-Based Diets Provide Robust Support forInsects · 2026Article
- Morin hydrate reduces survival and fertility, delays development and weakens lipid reserves in Aedes aegypti.Medical and veterinary entomology · 2025Article
- Response strategies of five common warm temperate plant species to insect defoliation.BMC ecology and evolution · 2024Article
- Evaluating the Effects of Flavonoids on Insects: Implications for Managing Pests Without Harming Beneficials.Insects · 2024Review
- Larvicidal potential of Trachyspermum ammi essential oil and Delphinium speciosum extract against malaria, dengue, and filariasis mosquito vectors.Scientific reports · 2024Article
- Article
- Versatility of Glutathione Transferase Proteins.Biomolecules · 2023Article
- Potent GST Ketosteroid Isomerase Activity Relevant to Ecdysteroidogenesis in the Malaria VectorBiomolecules · 2023Article
- Review
- Compounds Inhibiting Noppera-bo, a GlutathioneBiomolecules · 2023Review
- cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo.PloS one · 2023Article
Corrections and comments
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Authors and funding
25 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMosquito control is a crucial global issue for protecting the human community from mosquito-borne diseases. There is an urgent need for the development of selective and safe reagents for mosquito control. Flavonoids, a group of chemical substances with variable phenolic structures, such as daidzein, have been suggested as potential mosquito larvicides with less risk to the environment. However, the mode of mosquito larvicidal action of flavonoids has not been elucidated.
resultsHere, we report that several flavonoids, including daidzein, inhibit the activity of glutathione S-transferase Noppera-bo (Nobo), an enzyme used for the biosynthesis of the insect steroid hormone ecdysone, in the yellow fever mosquito Aedes aegypti. The crystal structure of the Nobo protein of Ae. aegypti (AeNobo) complexed with the flavonoids and its molecular dynamics simulation revealed that Glu113 forms a hydrogen bond with the flavonoid inhibitors. Consistent with this observation, substitution of Glu113 with Ala drastically reduced the inhibitory activity of the flavonoids against AeNobo. Among the identified flavonoid-type inhibitors, desmethylglycitein (4',6,7-trihydroxyisoflavone) exhibited the highest inhibitory activity in vitro. Moreover, the inhibitory activities of the flavonoids correlated with the larvicidal activity, as desmethylglycitein suppressed Ae. aegypti larval development more efficiently than daidzein.
conclusionOur study demonstrates the mode of action of flavonoids on the Ae. aegypti Nobo protein at the atomic, enzymatic, and organismal levels.
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