ArticleBMC pulmonary medicine2022
Tuberculosis contact tracing yield and associated factors in Uganda.
Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Facilitators and barriers to tuberculosis active case findings in low- and middle-income countries: a systematic review of qualitative research.BMC infectious diseases · 2023Pooled it
- Optimization of Case Finding and Preventive Treatment Among Household Contacts of People with Tuberculosis in Zimbabwe.Tropical medicine and infectious disease · 2025Article
- Shesha, a WhatsApp Chatbot for Linking Household Contacts to Tuberculosis Treatment or Preventive Therapy in South Africa: Design and Development.JMIR formative research · 2025Article
- The yield of tuberculosis contact investigation in São Paulo, Brazil: a community-based cross-sectional study.Epidemiology and infection · 2025Article
- Routine tuberculosis contact investigation yield and preventive treatment cascade in central Ethiopia.Heliyon · 2024Article
- The yield of tuberculosis contact investigation on relapsed TB patients and analysis of associated risk factors: Singapore's experience.Epidemiology and infection · 2024Article
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Authors and funding
4 authors.
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Abstract
backgroundThe yield of tuberculosis (TB) contact tracing is historically low in Uganda. We determined factors associated with a positive contact tracing yield at an urban public TB clinic in Kampala, Uganda.
methodsWe reviewed contact tracing registers of index TB cases registered between 2015 and 2020 at Kitebi Health Center, a primary level facility. Contacts who had symptoms of TB were designated as having presumptive TB. A contact investigation that yielded a new TB case was designated as a positive yield. We used logistic regression to determine factors associated with a positive yield of contact tracing.
resultsOf 778 index TB cases, 455 (58.5%) had a contact investigation conducted. Index cases with a telephone contact in the unit TB register (adjusted odds ratio (aOR) 1.66, 95% CI 1.02-1.97, p = 0.036) were more likely to have a contact investigation conducted than those who did not. Of 1350 contacts, 105 (7.8%) had presumptive TB. Of these, 73 (69.5%) were further evaluated for active TB and 29 contacts had active TB. The contact tracing yield for active TB was therefore 2.1% (29/1,350). The odds of a positive yield increased tenfold with each additional presumptive contact evaluated for active TB (aOR 10.1, 95% CI 2.95-34.66, p < 0.001). Also, retreatment index TB cases were more likely to yield a positive contact (aOR 7.69 95% CI 2.08-25.00, p = 0.002) than to new cases.
conclusionTB contact tracing should aim to evaluate all contacts with presumptive TB and contacts of retreatment cases to maximise the yield of contact tracing.
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