Evidence map›Paper›PMID 35172687›Full record

ArticleHuman vaccines & immunotherapeutics2022

Strategies to tackle SARS-CoV-2 Mu, a newly classified variant of interest likely to resist currently available COVID-19 vaccines.

Md Jamal Hossain, Ali A Rabaan, Abbas Al Mutair, Saad Alhumaid, Talha Bin Emran, G Saikumar, Saikat Mitra, Kuldeep Dhama

Abstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Md Jamal HossainDepartment of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.ORCID 0000-0001-9706-207X
Ali A RabaanMolecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.ORCID 0000-0002-6774-9847
Abbas Al MutairResearch Center, Almoosa Specialist Hospital, Al-Ahsa, Saudi Arabia.ORCID 0000-0002-9471-2767
Saad AlhumaidAdministration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa, Saudi Arabia.ORCID 0000-0003-4552-4513
Talha Bin EmranDepartment of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh.ORCID 0000-0003-3188-2272
G SaikumarDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India.ORCID 0000-0001-6492-4673
Saikat MitraDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Kuldeep DhamaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India.ORCID 0000-0001-7469-4752

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have recently been reported in many countries. These have exacerbated the coronavirus disease 2019 (COVID-19)-induced global health threats and hindered COVID-19 vaccine development and therapeutic progress. This commentary discusses the potential risk of the newly classified Mu variant of interest, seeming a highly vaccine-resistant variant, and the approaches that can be adopted to tackle this variant based on the available evidence. The SARS-CoV-2 B.1.621 (Mu variant) lineage has shown approximately ten times higher resistance to neutralizing sera obtained from COVID-19 survivors or BNT161b2-vaccinated people than the parenteral B.1 lineage. Several urgent and long-term strategic plans, including quick genomic surveillance for uncovering the genetic characteristics of the variants, equitable global mass vaccination, booster dose administration if required, and strict implementation of public health measures or non-pharmaceutical interventions, must be undertaken concertedly to restrict further infections, mutations, or recombination of the SARS-CoV-2 virus and its deadly strains.

Indexed as

COVID-19SARS-CoV-2COVID-19 VaccinesGenomicsHumansCOVID-19 Vaccinesgenomic surveillanceglobal mass vaccinationMu variantnon-pharmaceutical interventions (NPIs)SARS-CoV-2 B.1.621sub-lineage B.1.621.1vaccine breakthrough

Identifiers

PMID35172687
PMCPMC8862164

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.