Evidence map›Paper›PMID 35172604›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2022

Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment.

Alexandria M Doerfler, Jun Han, Kelsey E Jarrett, Li Tang, Antrix Jain, Alexander Saltzman, Marco De Giorgi, Marcel Chuecos, Ayrea E Hurley, Ang Li and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Alexandria M DoerflerMolecular Physiology and Biophysics Graduate Program (A.M.D., J.F.M., W.R.L.), University of California Los Angeles.
Jun HanBaylor College of Medicine, Houston, TX. Genome British Columbia Proteomics Centre (J.H., D.R.G.), University of California Los Angeles.
Kelsey E JarrettDepartment of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.
Li TangDepartment of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.
Antrix JainMass Spectrometry Proteomics Core (A.J., A.S., A.M.), University of California Los Angeles.ORCID 0000-0002-2815-3645
Alexander SaltzmanMass Spectrometry Proteomics Core (A.J., A.S., A.M.), University of California Los Angeles.ORCID 0000-0003-4166-9555
Marco De GiorgiDepartment of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.
Marcel ChuecosDepartment of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.ORCID 0000-0002-1840-0948
Ayrea E HurleyDepartment of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.
Ang LiDepartment of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.
Pauline MorandDepartment of Biological Chemistry (P.M., T.Q.d.A.V.), University of California Los Angeles.
Claudia AyalaDepartment of Molecular Physiology and Biophysics (A.M.D., K.E.J., L.T., M.D.G., M.C., A.E.H., A.L., C.A., J.F.M., W.R.L.), University of California Los Angeles.
David R GoodlettBaylor College of Medicine, Houston, TX. Genome British Columbia Proteomics Centre (J.H., D.R.G.), University of California Los Angeles.ORCID 0000-0002-8045-8200
Anna MalovannayaMass Spectrometry Proteomics Core (A.J., A.S., A.M.), University of California Los Angeles.
James F MartinMolecular Physiology and Biophysics Graduate Program (A.M.D., J.F.M., W.R.L.), University of California Los Angeles.ORCID 0000-0002-7842-9857
Thomas Q de Aguiar VallimUniversity of Victoria, BC, Canada. Division of Cardiology, Department of Medicine (K.E.J., T.Q.d.A.V.), University of California Los Angeles.
Noah ShroyerTranslational Biology and Molecular Medicine Graduate Program (M.C., J.F.M., N.S., W.R.L.), University of California Los Angeles.
William R LagorMolecular Physiology and Biophysics Graduate Program (A.M.D., J.F.M., W.R.L.), University of California Los Angeles.ORCID 0000-0002-1703-5125
MACOM (United States) · USUniversity of California, Los Angeles · USIONICS Mass Spectrometry (Canada) · CAAbterra Biosciences (United States) · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Molecular Physiology of the Cardiovascular SystemT32HL007676 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L · 1989 to 2020
$7.9M
Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM008231 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN · 1990 to 2019
$7.2M
Pitx2 in atrial fibrillationR01HL118761 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MARTIN, JAMES F · 2014 to 2025
$6.1M
Genetic Repair of Familial HypercholesterolemiaR01HL132840 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LAGOR, WILLIAM RAYMOND · 2017 to 2025
$5.4M
Hippo and Wnt Signaling in Cardiac RegenerationR01HL127717 · NHLBI · TEXAS HEART INSTITUTE · PI MARTIN, JAMES F · 2016 to 2023
$4.4M
Physiological Dissection of the Mevalonate PathwayR01DK124477 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI William Raymond Lagor, NOAH Freeman SHROYER · 2020 to 2026
$3.5M
BCM-Rice resource for the analysis of somatic gene editing in miceU42OD026645 · OD · BAYLOR COLLEGE OF MEDICINE · PI DICKINSON, MARY E, HEANEY, JASON D. · 2018 to 2022
$3.5M
Optical elastography for assessment of myocardial regenerationR01HL130804 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LARIN, KIRILL V, MARTIN, JAMES F · 2016 to 2019
$2.9M
American Heart Association-American Stroke Association 19POST34430092NCATS NIH HHS UL1 TR001873NCI NIH HHS P30 CA125123NHLBI NIH HHS R01 HL118761NHLBI NIH HHS R01 HL127717NHLBI NIH HHS R01 HL130804NHLBI NIH HHS R01 HL132840NHLBI NIH HHS T32 HL007676NHLBI NIH HHS T32 HL069766NHLBI NIH HHS UG3 HL151545NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK112119NIDDK NIH HHS R01 DK118064NIDDK NIH HHS R01 DK124477NIDDK NIH HHS R01 DK128952NIGMS NIH HHS T32 GM008231NIH HHS U42 OD026645
6 · The paper itself

Abstract

backgroundThe intestine occupies the critical interface between cholesterol absorption and excretion. Surprisingly little is known about the role of de novo cholesterol synthesis in this organ, and its relationship to whole body cholesterol homeostasis. Here, we investigate the physiological importance of this pathway through genetic deletion of the rate-limiting enzyme.

methodsMice lacking 3-hydroxy-3-methylglutaryl-coenzyme A reductase (

resultsMice with intestine-specific loss of

conclusionsLoss of

Indexed as

IntestinesStem CellsAcyl Coenzyme AAnimalsCholesterolFemaleMaleMiceSterols3-hydroxy-3-methylglutaryl-coenzyme AAcyl Coenzyme ACholesterolSterolsabsorptioncardiovascular diseasescholesterolintestinesstem cells

Identifiers

PMID35172604
PMCPMC8957608
OpenAlexW4213192976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.