ArticleAcute and critical care2022
Incidence and risk factors associated with early death in patients with emergency department septic shock.
Article in Acute and critical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Phenotype-specific dynamics of serum albumin and their impact on sepsis mortality.Biomarkers in medicine · 2025Observational
- Evaluation of the Diagnosis and Antibiotic Therapy of Sepsis in the Emergency Department: A Retrospective Observational Study.Biomedicines · 2025Article
- Using machine learning techniques for early prediction of tracheal intubation in patients with septic shock: a multi-center study in South Korea.Acute and critical care · 2025Article
- Early Prediction of Mortality for Septic Patients Visiting Emergency Room Based on Explainable Machine Learning: A Real-World Multicenter Study.Journal of Korean medical science · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited research has explored early mortality among patients presenting with septic shock. The objective of this study was to determine the incidence and factors associated with early death following emergency department (ED) presentation of septic shock.
methodsA prospective registry of patients enrolled in an ED septic shock clinical pathway was used to identify patients. Patients were compared across demographic, comorbid, clinical, and treatment variables by death within 72 hours of ED presentation.
resultsAmong the sample of 2,414 patients, overall hospital mortality was 20.6%. Among patients who died in the hospital, mean and median time from ED presentation to death were 4.96 days and 2.28 days, respectively. Death at 24, 48, and 72 hours occurred in 5.5%, 9.5%, and 11.5% of patients, respectively. Multivariate regression analysis demonstrated that the following factors were independently associated with early mortality: age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.03-1.05), malignancy (OR, 1.53; 95% CI, 1.11-2.11), pneumonia (OR, 1.39; 95% CI, 1.02-1.88), urinary tract infection (OR, 0.63; 95% CI, 0.44-0.89), first shock index (OR, 1.85; 95% CI, 1.27-2.70), early vasopressor use (OR, 2.16; 95% CI, 1.60-2.92), initial international normalized ratio (OR, 1.14; 95% CI, 1.07-1.27), initial albumin (OR, 0.55; 95% CI, 0.44-0.69), and first serum lactate (OR, 1.21; 95% CI, 1.16-1.26).
conclusionsAdult septic shock patients experience a high rate of early mortality within 72 hours of ED arrival. Recognizable clinical factors may aid the identification of patients at risk of early death.
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