ArticleAcute and critical care2022
Brain-lung interaction: a vicious cycle in traumatic brain injury.
Article in Acute and critical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic Factors Associated with Pneumonia in Patients with Traumatic Brain Injury: A Systematic Review and Meta-analysis.Neurocritical care · 2026Pooled it
- Does pneumonia increase the risk of dementia and cognitive decline? A systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Subcutaneous transplantation of lung organoids ameliorates vascular dementia via the IGFBP7-Ago2 mediated lung-brain axis.Journal of neuroinflammation · 2026Article
- The brain-lung axis: Bridging neurological and respiratory disorders via neural-immune-microbial dialogue.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Review
- The active role of pulmonary immunity in ischaemic stroke.Journal of neuroinflammation · 2026Review
- Epidemiology and Outcomes of Battlefield-Related Penetrating and Closed Traumatic Brain Injuries Compared to Non-Head Injuries: A Retrospective Cohort Study.Military medicine · 2026Article
- Efficacy of Ceftazidime/Avibactam versus colistin methanesulfonate in treating pulmonary infections caused by Gram-negative bacillis after craniocerebral surgery and analysis of risk factors influencing clinical outcomes: a retrospective study.BMC infectious diseases · 2026Article
- The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders.Journal of neuroinflammation · 2026Review
- A nomogram for predicting the risk of acute respiratory distress syndrome in patients with severe acute brain injury.BMC neurology · 2026Article
- Serum Hepcidin Levels are Associated with Poor Outcomes of Patients with Severe Traumatic Brain Injury: A Two-Center Observational Analytical Study.International journal of general medicine · 2026Article
- The impact of traumatic injury on the respiratory system; a narrative review of injury-associated and clinically-induced mechanisms of trauma-associated pneumonia.Frontiers in medicine · 2026Review
- Development and validation of nomogram for predicting neurogenic pulmonary edema in hypertensive intracerebral hemorrhage.Frontiers in cardiovascular medicine · 2026Article
- Early Prediction of Acute Respiratory Distress Syndrome in Critically Ill Polytrauma Patients Using Balanced Random Forest ML: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Review
- Pathophysiology and clinical applications of PEEP in acute brain injury.Intensive care medicine · 2025Review
- Lung protective ventilation alleviates intracerebral hemorrhage-induced secondary brain and lung injury in mice via the Nrf2/HO‑1 pathway.Journal of thoracic disease · 2025Article
- Brain Protective Ventilation Strategies in Severe Acute Brain Injury.Current neurology and neuroscience reports · 2025Review
- Directional interactions from non-small cell lung cancer to brain glucose metabolism revealed by total-body PET imaging.European journal of nuclear medicine and molecular imaging · 2025Article
- Association between traumatic brain injury and risk of developing infections in the central nervous system and periphery.Metabolic brain disease · 2025Review
- Admission braden scale is an effective marker for predicting pneumonia in critically ill patients with traumatic brain injury.Neurosurgical review · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain-lung interaction can seriously affect patients with traumatic brain injury, triggering a vicious cycle that worsens patient prognosis. Although the mechanisms of the interaction are not fully elucidated, several hypotheses, notably the "blast injury" theory or "double hit" model, have been proposed and constitute the basis of its development and progression. The brain and lungs strongly interact via complex pathways from the brain to the lungs but also from the lungs to the brain. The main pulmonary disorders that occur after brain injuries are neurogenic pulmonary edema, acute respiratory distress syndrome, and ventilator-associated pneumonia, and the principal brain disorders after lung injuries include brain hypoxia and intracranial hypertension. All of these conditions are key considerations for management therapies after traumatic brain injury and need exceptional case-by-case monitoring to avoid neurological or pulmonary complications. This review aims to describe the history, pathophysiology, risk factors, characteristics, and complications of brain-lung and lung-brain interactions and the impact of different old and recent modalities of treatment in the context of traumatic brain injury.
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