Evidence map›Paper›PMID 35172170›Full record

Observational studyAmerican journal of ophthalmology2022

Glaucomatous Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES): Eleven Years of Follow-up.

Bruna Melchior, Ives A Valenzuela, C Gustavo De Moraes, Jayter S Paula, Massimo A Fazio, Christopher A Girkin, James Proudfoot, George A Cioffi, Robert N Weinreb, Linda M Zangwill and 1 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Bruna MelchiorFrom the Bernard and Shirlee Brown Glaucoma Research Laboratory (B.M., I.A.V., G.D.M., G.A.C., J.M.L.), Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA; Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery (B.M., J.S.P.), Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Ives A ValenzuelaFrom the Bernard and Shirlee Brown Glaucoma Research Laboratory (B.M., I.A.V., G.D.M., G.A.C., J.M.L.), Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA.
C Gustavo De MoraesFrom the Bernard and Shirlee Brown Glaucoma Research Laboratory (B.M., I.A.V., G.D.M., G.A.C., J.M.L.), Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: cvd2109@cumc.columbia.edu.
Jayter S PaulaDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery (B.M., J.S.P.), Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Massimo A FazioDepartment of Ophthalmology (M.A.F., C.A.G.), University of Alabama-Birmingham, Birmingham, Alabama, USA.
Christopher A GirkinDepartment of Ophthalmology (M.A.F., C.A.G.), University of Alabama-Birmingham, Birmingham, Alabama, USA.
James ProudfootHamilton Glaucoma Center (J.P., R.N.W., L.M.Z.), Department of Ophthalmology, University of California-San Diego, La Jolla, California, USA.
George A CioffiFrom the Bernard and Shirlee Brown Glaucoma Research Laboratory (B.M., I.A.V., G.D.M., G.A.C., J.M.L.), Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA.
Robert N WeinrebHamilton Glaucoma Center (J.P., R.N.W., L.M.Z.), Department of Ophthalmology, University of California-San Diego, La Jolla, California, USA.
Linda M ZangwillHamilton Glaucoma Center (J.P., R.N.W., L.M.Z.), Department of Ophthalmology, University of California-San Diego, La Jolla, California, USA.
Jeffrey M LiebmannFrom the Bernard and Shirlee Brown Glaucoma Research Laboratory (B.M., I.A.V., G.D.M., G.A.C., J.M.L.), Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, USA.
Columbia University · USUniversity of California San Diego · USUniversidade de São Paulo · BRUniversity of Alabama at Birmingham · USColumbia University Irving Medical Center · US

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI J CRAWFORD DOWNS · 1985 to 2026
$16.9M
African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
VISUAL FUNCTION IN GLAUCOMA AND OCULAR HYPERTENSIONR01EY008208 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 1990 to 2010
$5.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
Structural and Functional Progression of Glaucomatous Damage to the MaculaR01EY025253 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE MORAES, CARLOS GUSTAVO · 2015 to 2017
$1.2M
Quantification of Glaucomatous Optic NeuropathyK23EY013959 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GIRKIN, CHRISTOPHER ANTHONY · 2002 to 2006
$994k
NEI NIH HHS K23 EY013959NEI NIH HHS P30 EY003039NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY008208NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY025253NEI NIH HHS R01 EY027510NEI NIH HHS U10 EY014267
6 · The paper itself

Abstract

purposeTo compare the rates of visual field (VF) progression between individuals of Black and White race and to investigate whether treatment effects may help explain differences previously reported between racial groups.

designMulticenter prospective observational cohort study.

methodsParticipants were patients in referral tertiary care glaucoma clinics with open angle glaucoma. Eyes were excluded who had <5 VF tests and <2 years of follow-up or any disease that could affect the optic nerve or the VF. The VF mean deviation (MD) slopes over time (dB/y) were calculated with linear regression models. Socioeconomic variables, rates of glaucoma surgery, medications, treated intraocular pressure (IOP), and central corneal thickness (CCT) were investigated.

resultsA total of 516 eyes were included with a mean (95% CI) follow-up time of 11.0 (range, 10.5-11.5) years and 15.0 (range, 14.1-15.8) visits. Participants of Black race were significantly younger (59.7 vs 66.9 years, P < .01) than those of White race. The mean CCT and socioeconomic variables were similar between Black and White groups (P = 0.20 and P = .56, respectively), as were treatment with topical medications (P = .90) and the rate of VF MD change (-0.24 [-0.31 to -0.17] dB/year vs -0.32 [-0.36 to -0.27], P = .11), despite higher treated mean IOP (14.9 [14.5 to 15.4] vs 14.0 [13.6 to 14.4] mm Hg, P = .03) and fewer trabeculectomies (29.5% vs 50.0%, P < .01) in the Black race group.

conclusionsRates of VF progression were similar despite higher treated IOP in the Black race group. Mitigation of health access disparities in this study may have equalized previously reported different rates of VF progression between racial groups.

Indexed as

GlaucomaGlaucoma, Open-AngleDisease ProgressionFollow-Up StudiesHumansIntraocular PressureProspective StudiesVision DisordersVisual FieldsVisual Field TestsGlaucomavisual field, race, socioeconomics

Identifiers

PMID35172170
PMCPMC9233143
OpenAlexW4213232771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.