ArticleCell reports2022
Input rate encoding and gain control in dendrites of neocortical pyramidal neurons.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- An in silico framework for dissecting the mechanistic origins of in vivo recorded neuronal activity.PLoS computational biology · 2026Article
- Interplay between store-operated calcium entry and mitochondrial phosphate handling modulates force and fatigue during exercise.bioRxiv : the preprint server for biology · 2026Article
- Midazolam Exerts Sedative Effects by Differentially Modulating Cortical Pyramidal Neurons and PV Interneurons.CNS neuroscience & therapeutics · 2026Article
- Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons.Research square · 2025Article
- Nonlinear Dendritic Integration Supports Up-Down States in Single Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dendritic synaptic integration modes under in vivo-like states.Biophysical journal · 2025Article
- Temporal integration on the dendrites of fast-spiking basket cells.Scientific reports · 2024Article
- Probing multiplexed basal dendritic computations using two-photon 3D holographic uncaging.Cell reports · 2024Article
- Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex.Current research in neurobiology · 2024Review
- Low throughput screening in neuroscience: using light to study central synapses one at a time.Neurophotonics · 2023Article
- Asymmetric Voltage Attenuation in Dendrites Can Enable Hierarchical Heterosynaptic Plasticity.eNeuro · 2023Article
- Spatial integration of dendrites in fast-spiking basket cells.Frontiers in neuroscience · 2023Article
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2 authors.
Funding
Abstract
Elucidating how neurons encode network activity is essential to understanding how the brain processes information. Neocortical pyramidal cells receive excitatory input onto spines distributed along dendritic branches. Local dendritic branch nonlinearities can boost the response to spatially clustered and synchronous input, but how this translates into the integration of patterns of ongoing activity remains unclear. To examine dendritic integration under naturalistic stimulus regimes, we use two-photon glutamate uncaging to repeatedly activate multiple dendritic spines at random intervals. In the proximal dendrites of two populations of layer 5 pyramidal neurons in the mouse motor cortex, spatially restricted synchrony is not a prerequisite for dendritic boosting. Branches encode afferent inputs with distinct rate sensitivities depending upon cell and branch type. Thus, inputs distributed along a dendritic branch can recruit supralinear boosting and the window of this nonlinearity may provide a mechanism by which dendrites can preferentially amplify slow-frequency network oscillations.
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