Evidence map›Paper›PMID 35172051›Full record

ArticleThe New England journal of medicine2022

Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection.

Victoria Hall, Sarah Foulkes, Ferdinando Insalata, Peter Kirwan, Ayoub Saei, Ana Atti, Edgar Wellington, Jameel Khawam, Katie Munro, Michelle Cole and 25 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New England journal of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 437 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
437citing papers in PubMed, 1 pooled it
73.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

437 citing papers in PubMed, 1 synthesis or guideline pooled it, 742 citations in OpenAlex.

  1. Pooled it
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  15. Olfactory immunity: defending the neural-mucosal barrier.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
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377 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 6 institutions in 2 countries.

Victoria HallFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.ORCID 0000-0001-8744-4277
Sarah FoulkesFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Ferdinando InsalataFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Peter KirwanFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.ORCID 0000-0001-6904-0500
Ayoub SaeiFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Ana AttiFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.ORCID 0000-0001-6768-6586
Edgar WellingtonFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Jameel KhawamFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Katie MunroFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Michelle ColeFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Caio TranquilliniFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.ORCID 0000-0001-9478-2557
Andrew Taylor-KerrFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Nipunadi HettiarachchiFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Davina CalbraithFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Noshin SajediFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.ORCID 0000-0001-7550-894X
Iain MilliganFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Yrene ThemistocleousFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Diane CorriganFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Lisa CromeyFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Lesley PriceFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Sally StewartFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Elen de LacyFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Chris NormanFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Ezra LinleyFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Ashley D OtterFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Amanda SemperFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Jacqueline HewsonFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Silvia D'ArcangeloFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Meera ChandFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Colin S BrownFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Tim BrooksFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.ORCID 0000-0002-3783-1284
Jasmin IslamFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Andre CharlettFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
Susan HopkinsFrom the U.K. Health Security Agency (V.H., S.F., F.I., P.K., A. Saei, A.A., E.W., J.K., K.M., M. Cole, C.T., A.T.-K., N.H., D. Calbraith, N.S., I.M., Y.T., E. Linley, A.D.O., A. Semper, J.H., S.D., M. Chand, C.S.B., T.B., J.I., A.C., S.H.), Guy's and St. Thomas' NHS Foundation Trust (M. Chand), and the National Institute for Health Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London School of Hygiene and Tropical Medicine, in partnership with Public Health England (A.C.), London, the Health Protection Research NIHR Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford (V.H., C.S.B., S.H.), the Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge (P.K.), the Public Health Agency Northern Ireland, Belfast (D. Corrigan, L.C.), Glasgow Caledonian University and Public Health Scotland, Glasgow (L.P., S.S.), Public Health Wales (E. Lacy) and Health and Care Research Wales (C.N.), Cardiff, and the NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, in partnership with Public Health England, Bristol (A.C.) - all in the United Kingdom.
SIREN Study Group
Anna Needs Neuroblastoma Answers · USUniversity of Liverpool · GBGlasgow Caledonian University · GBGuy's and St Thomas' NHS Foundation Trust · GBPublic Health England · GBUniversity of Cambridge · GB

Funding

Medical Research Council MC_PC_20060Medical Research Council MC_UU_00002/11Medical Research Council MR/W02067X/1
6 · The paper itself

Abstract

backgroundThe duration and effectiveness of immunity from infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relevant to pandemic policy interventions, including the timing of vaccine boosters.

methodsWe investigated the duration and effectiveness of immunity in a prospective cohort of asymptomatic health care workers in the United Kingdom who underwent routine polymerase-chain-reaction (PCR) testing. Vaccine effectiveness (≤10 months after the first dose of vaccine) and infection-acquired immunity were assessed by comparing the time to PCR-confirmed infection in vaccinated persons with that in unvaccinated persons, stratified according to previous infection status. We used a Cox regression model with adjustment for previous SARS-CoV-2 infection status, vaccine type and dosing interval, demographic characteristics, and workplace exposure to SARS-CoV-2.

resultsOf 35,768 participants, 27% (9488) had a previous SARS-CoV-2 infection. Vaccine coverage was high: 95% of the participants had received two doses (78% had received BNT162b2 vaccine [Pfizer-BioNTech] with a long interval between doses, 9% BNT162b2 vaccine with a short interval between doses, and 8% ChAdOx1 nCoV-19 vaccine [AstraZeneca]). Between December 7, 2020, and September 21, 2021, a total of 2747 primary infections and 210 reinfections were observed. Among previously uninfected participants who received long-interval BNT162b2 vaccine, adjusted vaccine effectiveness decreased from 85% (95% confidence interval [CI], 72 to 92) 14 to 73 days after the second dose to 51% (95% CI, 22 to 69) at a median of 201 days (interquartile range, 197 to 205) after the second dose; this effectiveness did not differ significantly between the long-interval and short-interval BNT162b2 vaccine recipients. At 14 to 73 days after the second dose, adjusted vaccine effectiveness among ChAdOx1 nCoV-19 vaccine recipients was 58% (95% CI, 23 to 77) - considerably lower than that among BNT162b2 vaccine recipients. Infection-acquired immunity waned after 1 year in unvaccinated participants but remained consistently higher than 90% in those who were subsequently vaccinated, even in persons infected more than 18 months previously.

conclusionsTwo doses of BNT162b2 vaccine were associated with high short-term protection against SARS-CoV-2 infection; this protection waned considerably after 6 months. Infection-acquired immunity boosted with vaccination remained high more than 1 year after infection. (Funded by the U.K. Health Security Agency and others; ISRCTN Registry number, ISRCTN11041050.).

Indexed as

Adaptive ImmunityCOVID-19COVID-19 VaccinesSARS-CoV-2Asymptomatic DiseasesBNT162 VaccineChAdOx1 nCoV-19COVID-19 Nucleic Acid TestingHealth PersonnelHumansProspective StudiesUnited KingdomVaccinationVaccine EfficacyBNT162 VaccineChAdOx1 nCoV-19COVID-19 Vaccines

Identifiers

PMID35172051
PMCPMC8908850
OpenAlexW4212835565

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.