ArticleScience advances2022
Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life.The EMBO journal · 2026Article
- Molecular Characterization of PARP Inhibitor Response Reveals Co-Targeting Strategies in Advanced Prostate Cancer.Cancers · 2026Article
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Dendrobium officinale leaf extract extends the mean lifespan in Caenorhabditis elegans via the DAF-16/SOD-3 axis.Biogerontology · 2026Article
- ATGL sensitizes hepatocellular carcinoma cells to genotoxic drugs by modulating p53 acetylation/phosphorylation status.Cell death discovery · 2026Article
- MicroRNA strand ratio disarray promotes temozolomide resistance in glioblastoma.Cellular & molecular biology letters · 2025Article
- Immunoinflammation and post-translational modifications in the aging process.Journal of translational medicine · 2025Review
- ATR promotes mTORC1 activity via de novo cholesterol synthesis.EMBO reports · 2025Article
- Chromatin and epigenetics in aging biology.Genetics · 2025Review
- Beyond polarization: macrophage senescence in immunoregulation and cancer therapy.International journal of biological sciences · 2025Review
- Mitochondrial fatty acid oxidation drives senescence.Science advances · 2024Article
- Hyperacetylated histone H4 is a source of carbon contributing to lipid synthesis.The EMBO journal · 2024Article
- A molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.Aging cell · 2024Article
- Evaluation of inflammatory hyperreflective foci and plasma EPA as diagnostic and predictive markers for age-related macular degeneration.Frontiers in neuroscience · 2024Article
- Acetyltransferase in cardiovascular disease and aging.The journal of cardiovascular aging · 2024Article
- Too old for healthy aging? Exploring age limits of longevity treatments.npj metabolic health and disease · 2024Review
- Transcriptional changes of the aging lung.Aging cell · 2023Article
- Inflammation and DNA damage: cause, effect or both.Nature reviews. Rheumatology · 2023Review
- Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer's Disease.Molecular & cellular proteomics : MCP · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Shruthi HamsanathanAging Institute of UPMC and the University of Pittsburgh School of Medicine, 100 Technology Dr., Pittsburgh, PA 15219, USA.ORCID 0000-0002-6613-180X
Tamil AnthonymuthuDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.ORCID 0000-0002-3460-5003
Suhao HanAging Institute of UPMC and the University of Pittsburgh School of Medicine, 100 Technology Dr., Pittsburgh, PA 15219, USA.
Himaly ShinglotAging Institute of UPMC and the University of Pittsburgh School of Medicine, 100 Technology Dr., Pittsburgh, PA 15219, USA.
Ella SiefkenAging Institute of UPMC and the University of Pittsburgh School of Medicine, 100 Technology Dr., Pittsburgh, PA 15219, USA.ORCID 0000-0002-9931-248X
Austin SimsAging Institute of UPMC and the University of Pittsburgh School of Medicine, 100 Technology Dr., Pittsburgh, PA 15219, USA.ORCID 0000-0002-1509-8421
Payel SenLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.ORCID 0000-0003-2809-0901
Hannah L PepperCenter for Metabolic Disease Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0001-8931-7706
Nathaniel W SnyderCenter for Metabolic Disease Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Hulya BayirDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.ORCID 0000-0003-2361-4120
Valerian KaganChildren's Neuroscience Institute, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA.ORCID 0000-0002-7245-1885
Aditi U GurkarAging Institute of UPMC and the University of Pittsburgh School of Medicine, 100 Technology Dr., Pittsburgh, PA 15219, USA.ORCID 0000-0003-4338-0624
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0MTraining and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENBERGER, JOEL S · 2005 to 2019
$44.4MRegulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MEpigenetic mechanisms of mammalian tissue agingZIAAG000679 · NIA · NATIONAL INSTITUTE ON AGING · PI SEN, PAYEL · 2019 to 2025
$6.9MMapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric ImagingR01NS076511 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir, Valerian E Kagan · 2012 to 2026
$6.8MLipids and Myeloid Cell Function in CancerR01CA165065 · NCI · WISTAR INSTITUTE · PI KAGAN, VALERIAN E, MONTANER, LUIS J · 2012 to 2022
$3.8MOxidative Lipidomics in Pediatric Traumatic Brain InjuryR01NS061817 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2008 to 2018
$3.3MProtein-Oxidized Phospholipid Interactions Determine Epithelial Cell Fate and Asthma Control R01AI145406 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sally E Wenzel · 2020 to 2026
$2.9MRegulation of tumor recurrence by stress activated neutrophilsR01CA243142 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2020 to 2025
$2.8MRadiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos PyroptosisU01AI156923 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2020 to 2024
$2.4MSelective Inhibitors of Pro-Ferroptotic Lipoxygenases - Next Generation RadiomitigatorsU01AI156924 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAGAN, VALERIAN E · 2020 to 2024
$2.3MIntramural NIH HHS ZIA AG000679NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA165065NCI NIH HHS R01 CA243142NHLBI NIH HHS P01 HL114453NIAID NIH HHS R01 AI145406NIAID NIH HHS U01 AI156923NIAID NIH HHS U01 AI156924NIAID NIH HHS U19 AI068021NIA NIH HHS R00 AG049126NIGMS NIH HHS R01 GM113908NIGMS NIH HHS R01 GM132261NIH HHS P40 OD010440NIH HHS S10 OD023402NINDS NIH HHS R01 NS061817NINDS NIH HHS R01 NS076511NINDS NIH HHS R37 NS061817
Abstract
Although DNA damage is intricately linked to metabolism, the metabolic alterations that occur in response to DNA damage are not well understood. We use a DNA repair-deficient model of ERCC1-XPF in
Indexed as
DNA RepairHistonesAnimalsCaenorhabditis elegansDNA DamageLipid MetabolismHistones
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.