Evidence map›Paper›PMID 35171619›Full record

ArticleThe journal of physical chemistry. B2022

Thermodynamic Driving Forces of Redox-Dependent CPR Insertion into Biomimetic Endoplasmic Reticulum Membranes.

Michael J Martinez, Jessica D Carder, Evan L Taylor, Eric P Jacobo, ChulHee Kang, J A Brozik

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Thermodynamics andThe journal of physical chemistry. B · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michael J MartinezDepartment of Chemistry, Washington State University, Pullman, Washington 99163-4630, United States.
Jessica D CarderDepartment of Chemistry, Washington State University, Pullman, Washington 99163-4630, United States.
Evan L TaylorMaterials Science & Engineering Program, Washington State University, Pullman, Washington 99163-2711, United States.ORCID 0000-0002-6460-1871
Eric P JacoboDepartment of Chemistry, Washington State University, Pullman, Washington 99163-4630, United States.
ChulHee KangDepartment of Chemistry, Washington State University, Pullman, Washington 99163-4630, United States.
J A BrozikDepartment of Chemistry, Washington State University, Pullman, Washington 99163-4630, United States.ORCID 0000-0003-2097-5051
Washington State University · US

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

Cytochrome P450 reductase (CPR) is a NADPH-dependent membrane-bound oxidoreductase found in the endoplasmic reticulum (ER) and is the main redox partner for most cytochrome P450 enzymes. Presented are the measured thermodynamic driving forces responsible for how strongly CPR partitions into a biomimetic ER with the same lipid composition of a natural ER. Using temperature-dependent fluorescence correlation spectroscopy and fluorescence single-protein tracking, the standard state free energies, enthalpies, and entropies of the CPR insertion process were all measured. The results of this study demonstrate that the thermodynamic driving forces are dependent on the redox states of CPR. In particular, the partitioning of CPR

Indexed as

Cardiopulmonary ResuscitationNADPH-Ferrihemoprotein ReductaseBiomimeticsCytochrome P-450 Enzyme SystemEndoplasmic ReticulumOxidation-ReductionThermodynamicsCytochrome P-450 Enzyme SystemNADPH-Ferrihemoprotein Reductase

Identifiers

PMID35171619
PMCPMC9494945
OpenAlexW4212967548

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.