Evidence map›Paper›PMID 35171608›Full record

ArticleInorganic chemistry2022

Glucosyl Platinum(II) Complexes Inhibit Aggregation of the C-Terminal Region of the Aβ Peptide.

Sara La Manna, Marilisa Leone, Ilaria Iacobucci, Alfonso Annuziata, Concetta Di Natale, Elena Lagreca, Anna Maria Malfitano, Francesco Ruffo, Antonello Merlino, Maria Monti and 1 more

Abstract read
In one paragraph

Article in Inorganic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Mechanism of Metal Complexes in Alzheimer's Disease.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. Metal Complexes as Promising Matrix Metalloproteinases Regulators.International journal of molecular sciences · 2023
    Review
  8. Peptide-Based Materials That Exploit Metal Coordination.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara La MannaDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.
Marilisa LeoneInstitute of Biostructures and Bioimaging - CNR, 80134 Naples, Italy.ORCID https://orcid.org/0000-0002-3811-6960
Ilaria IacobucciDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.
Alfonso AnnuziataDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.
Concetta Di NataleInterdisciplinary Research Centre on Biomaterials (CRIB), Department of Ingegneria Chimica del Materiali e della Produzione Industriale (DICMAPI), University "Federico II", 80125 Naples, Italy.ORCID https://orcid.org/0000-0002-2874-6539
Elena LagrecaInterdisciplinary Research Centre on Biomaterials (CRIB), Department of Ingegneria Chimica del Materiali e della Produzione Industriale (DICMAPI), University "Federico II", 80125 Naples, Italy.
Anna Maria MalfitanoDepartment of Translational Medical Science, University of Naples "Federico II", 80131 Naples, Italy.
Francesco RuffoDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.ORCID https://orcid.org/0000-0003-1624-079X
Antonello MerlinoDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.ORCID https://orcid.org/0000-0002-1045-7720
Maria MontiDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.ORCID https://orcid.org/0000-0002-7775-7154
Daniela MarascoDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-6618-2949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases are often caused by uncontrolled amyloid aggregation. Hence, many drug discovery processes are oriented to evaluate new compounds that are able to modulate self-recognition mechanisms. Herein, two related glycoconjugate pentacoordinate Pt(II) complexes were analyzed in their capacity to affect the self-aggregation processes of two amyloidogenic fragments, Aβ

Indexed as

Amyloid beta-PeptidesCoordination ComplexesGlucosidesHumansOrganoplatinum CompoundsPeptide FragmentsPlatinumProtein AggregatesAmyloid beta-PeptidesCoordination ComplexesGlucosidesOrganoplatinum CompoundsPeptide FragmentsPlatinumProtein Aggregates

Identifiers

PMID35171608
PMCPMC9951207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.