Evidence map›Paper›PMID 35171346›Full record

ReviewEuropean biophysics journal : EBJ2022

Micropipette-based biomechanical nanotools on living cells.

Haoqing Wang, Fang Zhou, Yuze Guo, Lining Arnold Ju

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European biophysics journal : EBJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
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  6. Article
  7. Review
  8. Review
  9. Article
  10. Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Nanoengineering for Mechanobiology "N4M-20".European biophysics journal : EBJ · 2022
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Haoqing Wang *School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia.
Fang Zhou *School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia.
Yuze GuoSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia.
Lining Arnold JuSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia. arnold.ju@sydney.edu.au.ORCID http://orcid.org/0000-0002-7591-0864
The University of Sydney · AU

Funding

Australian Research Council Discovery Project DP200101970National Health and Medical Research Council APP2003904NSW Cardiovascular Capacity Building Program Early-Mid Career Researcher GrantRamaciotti Foundations 2020HIG76Sydney Research Accelerator prize SOAR
6 · The paper itself

Abstract

Mechanobiology is an emerging field at the interface of biology and mechanics, investigating the roles of mechanical forces within biomolecules, organelles, cells, and tissues. As a highlight, the recent advances of micropipette-based aspiration assays and dynamic force spectroscopies such as biomembrane force probe (BFP) provide unprecedented mechanobiological insights with excellent live-cell compatibility. In their classic applications, these assays measure force-dependent ligand-receptor-binding kinetics, protein conformational changes, and cellular mechanical properties such as cortical tension and stiffness. In recent years, when combined with advanced microscopies in high spatial and temporal resolutions, these biomechanical nanotools enable characterization of receptor-mediated cell mechanosensing and subsequent organelle behaviors at single-cellular and molecular level. In this review, we summarize the latest developments of these assays for live-cell mechanobiology studies. We also provide perspectives on their future upgrades with multimodal integration and high-throughput capability.

Indexed as

Mechanical PhenomenaProteinsBiomechanical PhenomenaBiophysicsKineticsLigandsLigandsProteinsCortical tensionDynamic force spectroscopyMechanobiologyMicropipette

Identifiers

PMID35171346
PMCPMC8964576
OpenAlexW4213318317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.