Evidence map›Paper›PMID 35171013›Full record

ArticleMicrobiology spectrum2022

Characterization of Amino Acid Substitution W20S in MgrB Involved in Polymyxin Resistance in Klebsiella pneumoniae.

Mélanie Roch, Willames M B S Martins, Roberto Sierra, Ana C Gales, Diego O Andrey

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Global prevalence of mutation in theFrontiers in microbiology · 2024
    Pooled it
  2. Polymyxin-resistant hypervirulentFrontiers in microbiology · 2025
    Article
  3. Polymyxin Resistance in Clinical Isolates ofFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Mélanie RochDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-6485-8434
Willames M B S MartinsDepartment of Medical Microbiology, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-3001-3625
Roberto SierraService of Infectious Diseases, Department of Medicine, Geneva University Hospitals and Medical School, Geneva, Switzerland.ORCID 0000-0002-8657-1781
Ana C GalesUniversidade Federal de São Paulo - UNIFESP, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo, Brazil.
Diego O AndreyService of Infectious Diseases, Department of Medicine, Geneva University Hospitals and Medical School, Geneva, Switzerland.ORCID 0000-0003-3247-9274
University of Geneva · CHCardiff University · GBUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the major human pathogen Klebsiella pneumoniae, MgrB inactivation by disruptive insertion sequence (IS) elements and mutations leading to early termination are known to play an important role in polymyxin resistance. In this study, we examined a collection of invasive

Indexed as

Amino Acid SubstitutionDrug Resistance, BacterialAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesHumansKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsMutation, MissensePolymyxin BAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesPolymyxin BcolistinEnterobacteralesKPCmultidrug resistance

Identifiers

PMID35171013
PMCPMC8849082
OpenAlexW4213092254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.