Evidence map›Paper›PMID 35170971›Full record

ArticleMolecular pharmaceutics2022

Structurally Related Liposomes Containing

Sara Battista, Pierangelo Bellio, Lorenza Fagnani, Elena Allegritti, Lisaurora Nazzicone, Luciano Galantini, Giuseppe Celenza, Luisa Giansanti

Open access · hybridAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sara BattistaDipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila, Via Vetoio 10, 67010 Coppito, AQ, Italy.
Pierangelo BellioDipartimento di Scienze Chimiche Applicate e Biotecnologie, Università degli Studi dell'Aquila, Via Vetoio 10, 67010 Coppito, AQ, Italy.
Lorenza FagnaniDipartimento di Scienze Chimiche Applicate e Biotecnologie, Università degli Studi dell'Aquila, Via Vetoio 10, 67010 Coppito, AQ, Italy.
Elena AllegrittiDipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila, Via Vetoio 10, 67010 Coppito, AQ, Italy.
Lisaurora NazziconeDipartimento di Scienze Chimiche Applicate e Biotecnologie, Università degli Studi dell'Aquila, Via Vetoio 10, 67010 Coppito, AQ, Italy.
Luciano GalantiniDipartimento di Chimica, Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.ORCID 0000-0001-5484-2658
Giuseppe CelenzaDipartimento di Scienze Chimiche Applicate e Biotecnologie, Università degli Studi dell'Aquila, Via Vetoio 10, 67010 Coppito, AQ, Italy.
Luisa GiansantiDipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila, Via Vetoio 10, 67010 Coppito, AQ, Italy.ORCID 0000-0001-9056-0607
University of L'Aquila · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although liposomes are largely investigated as drug delivery systems, they can also exert a pharmacological activity if devoid of an active principle as a function of their composition. Specifically, charged liposomes can electrostatically interact with bacterial cells and, in some cases, induce bacterial cell death. Moreover, they also show a high affinity toward bacterial biofilms. We investigated the physicochemical and antimicrobial properties of liposomes formulated with a natural phospholipid and four synthetic l-prolinol-derived surfactants at 9/1 and 8/2 molar ratios. The synthetic components differ in the nature of the polar headgroup (quaternary ammonium salt or

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsGram-Positive BacteriaLiposomesMicrobial Sensitivity TestsOxidesStaphylococcus epidermidisSurface-Active AgentsAnti-Bacterial AgentsAnti-Infective AgentsLiposomesOxidesSurface-Active Agentsantibacterial activityliposomesl-prolinol derivativesstructure−activity relationsynergistic effect

Identifiers

PMID35170971
PMCPMC8905576
OpenAlexW4213268683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.