SynthesisJournal of the European Academy of Dermatology and Venereology : JEADV2022
Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.
Synthesis in Journal of the European Academy of Dermatology and Venereology : JEADV, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.Health technology assessment (Winchester, England) · 2024Trial
- Unraveling the Natural History of Atopic Dermatitis: Prospective Disease Trajectories and Longitudinal IgE Sensitization from Birth to Adolescence.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Multidisciplinary Delphi Consensus on management of children with moderate-severe atopic dermatitis.Italian journal of pediatrics · 2026Article
- The Patient Voice in Atopic Eczema Guidelines: How Do We Make it Standard Practice?The patient · 2026Review
- Clinical Validation of the Updated Korean Atopic Dermatitis Diagnostic Criteria in a Hospital Setting in South Korea.Annals of dermatology · 2025Article
- Novel drug delivery systems in topical treatment of atopic dermatitis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- PeiTuQingXin formula alleviated atopic dermatitis symptoms via inhibiting TRADD/TRAF2/RIP1 complex mediated NF-κB signaling pathway activation.Archives of dermatological research · 2025Article
- Counselling Needs in Atopic Dermatitis: Perspectives on Pregnancy and Treatment.Acta dermato-venereologica · 2025Article
- Dual Relief: How Atopic Dermatitis Treatments Affect Alopecia Areata-A Small Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2025Article
- Effectiveness of Tralokinumab in Different Phenotypes of Atopic Dermatitis: A Real-World Study.Dermatology and therapy · 2025Article
- Predictors for the Efficacy of 4-Week Dupilumab Treatment in Atopic Dermatitis Patients.Journal of asthma and allergy · 2025Article
- Neural-Inflammation Mechanism of Spinal Palmitic Acid Promoting Atopic Dermatitis in Mice.Journal of inflammation research · 2025Article
- Machine learning-derived phenotypic trajectories of asthma and allergy in children and adolescents: protocol for a systematic review.BMJ open · 2024Article
- Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China.Frontiers of medicine · 2024Article
- Blocking the IL-4/IL-13 Axis versus the JAK/STAT Pathway in Atopic Dermatitis: How Can We Choose?Journal of personalized medicine · 2024Review
- Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research: an interdisciplinary perspective.The British journal of dermatology · 2024Review
- The role of the environment in allergic skin disease.Current allergy and asthma reports · 2024Review
- Association between Outdoor and Indoor Air Pollution Sources and Atopic Eczema among Preschool Children in South Africa.International journal of environmental research and public health · 2024Article
- Burden of Disease and Unmet Needs in the Diagnosis and Management of Atopic Dermatitis in Diverse Skin Types in Australia.Journal of clinical medicine · 2023Review
- How to Understand Personalized Medicine in Atopic Dermatitis Nowadays?International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reported phenotypes of atopic dermatitis and any characteristics associated with them. Ovid EMBASE, Ovid MEDLINE and Web of Science were searched from inception till 12 February 2021 for studies attempting to classify atopic dermatitis. Primary outcomes are atopic dermatitis phenotypes and characteristics associated with them in subsequent analyses. A secondary outcome is the methodological approach used to derive them. In total, 8511 records were found. By focussing only on certain clinical phenotypes, 186 studies were eligible for inclusion. The majority of studies were hospital-based (59%, 109/186) and cross-sectional (76%, 141/186). The number of included patients ranged from seven to 526 808. Data-driven approaches to identify phenotypes were only used in a minority of studies (7%, 13/186). Ninety-one studies (49%) investigated a phenotype based on disease severity. A phenotype based on disease trajectory, morphology and eczema herpeticum was investigated in 56 (30%), 22 (12%) and 11 (6%) studies respectively. Thirty-six studies (19%) investigated morphological characteristics in other phenotypes. Investigated associated characteristics differed between studies. In conclusion, we present an overview of phenotype definitions used in literature for severity, trajectory, morphology and eczema herpeticum, including associated characteristics. There is a lack of uniform and consistent use of atopic dermatitis phenotypes across studies.
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