ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2022
Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Optimal Organelle Inheritance Strategies Under Different Changing Environments and Mutational Pressures.Genome biology and evolution · 2026Article
- Unstable mitochondrial heteroplasmy inPeerJ · 2026Article
- Gatekeepers of the Germ Line: How Mitochondria Shape Reproductive Evolution in Metazoans.Biology · 2025Review
- New insights into mitochondrial segregation from the Doubly Uniparental Inheritance system in bivalves.BMC biology · 2025Article
- Sex-Specific ORFs in Marine Clams (Bivalvia: Veneridae) with Doubly Uniparental Inheritance: Exploring Their Origin and Putative Function.Marine biotechnology (New York, N.Y.) · 2025Article
- Occurrence of Intersex in the Marine MusselBiology · 2025Article
- Demystifying the functions of the mitochondrial ORFan proteins in bivalves with doubly uniparental inheritance.Biology letters · 2025Article
- Mitonuclear compatibility is maintained despite relaxed selection on male mitochondrial DNA in bivalves with doubly uniparental inheritance.Evolution; international journal of organic evolution · 2024Article
- Mitochondrion-to-nucleus communication mediated by RNA export: a survey of potential mechanisms and players across eukaryotes.Biology letters · 2024Review
- High heteroplasmy is associated with low mitochondrial copy number and selection against non-synonymous mutations in the snail Cepaea nemoralis.BMC genomics · 2024Article
- The Effects of DNA Methylation on Cytoplasmic Male Sterility in Sugar Beet.International journal of molecular sciences · 2024Article
- Mitonuclear Sex Determination? Empirical Evidence from Bivalves.Molecular biology and evolution · 2023Article
- Bivalves as Emerging Model Systems to Study the Mechanisms and Evolution of Sex Determination: A Genomic Point of View.Genome biology and evolution · 2023Article
- LAMP-based molecular sexing in a gonochoric marine bivalve (Ecology and evolution · 2023Article
- A tale of two paths: The evolution of mitochondrial recombination in bivalves with doubly uniparental inheritance.The Journal of heredity · 2023Article
- The longest mitochondrial protein in metazoans is encoded by the male-transmitted mitogenome of the bivalveBiology letters · 2022Article
- The male-type mitochondrial genome of the freshwater musselMitochondrial DNA. Part B, Resources · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Animal and plant species exhibit an astonishing diversity of sexual systems, including environmental and genetic determinants of sex, with the latter including genetic material in the mitochondrial genome. In several hermaphroditic plants for example, sex is determined by an interaction between mitochondrial cytoplasmic male sterility (CMS) genes and nuclear restorer genes. Specifically, CMS involves aberrant mitochondrial genes that prevent pollen development and specific nuclear genes that restore it, leading to a mixture of female (male-sterile) and hermaphroditic individuals in the population (gynodioecy). Such a mitochondrial-nuclear sex determination system is thought to be rare outside plants. Here, we present one possible case of CMS in animals. We hypothesize that the only exception to the strict maternal mtDNA inheritance in animals, the doubly uniparental inheritance (DUI) system in bivalves, might have originated as a mitochondrial-nuclear sex-determination system. We document and explore similarities that exist between DUI and CMS, and we propose various ways to test our hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.