Evidence map›Paper›PMID 35170593›Full record

ArticleChemical communications (Cambridge, England)2022

A self-immolative linker that releases thiols detects penicillin amidase and nitroreductase with high sensitivity

Eli M Espinoza, Joachim J Røise, Maomao He, I-Che Li, Alvin K Agatep, Patrick Udenyi, Hesong Han, Nicole Jackson, D Lucas Kerr, Dake Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eli M EspinozaDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.ORCID http://orcid.org/0000-0002-0134-2833
Joachim J RøiseDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.ORCID http://orcid.org/0000-0002-1794-7570
Maomao HeDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.
I-Che LiDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.
Alvin K AgatepDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.
Patrick UdenyiDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Hesong HanDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.
Nicole JacksonSchool of Public Health, Division of Infectious Diseases and Vaccinology, University of California Berkeley, Berkeley, CA, USA. lwriley@berkeley.edu.
D Lucas KerrDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID http://orcid.org/0000-0002-0557-8341
Dake ChenDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.
Michael R StentzelDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.
Emily RuanDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Lee RileySchool of Public Health, Division of Infectious Diseases and Vaccinology, University of California Berkeley, Berkeley, CA, USA. lwriley@berkeley.edu.
Niren MurthyDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. nmurthy@berkeley.edu.ORCID http://orcid.org/0000-0002-7815-7337

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Dissemination and Coordinating Center for the SCGE ConsortiumU24HG010423 · NHGRI · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MELINDA R · 2019 to 2023
$15.0M
Consortium for drug-resistant Gram-negative pathogen detectionR01AI117064 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEE, LUKE P., MURTHY, NIREN · 2015 to 2019
$5.7M
Development of a Nanoparticle-Based Gene Editing Technology for Neurological ApplicationsUG3NS115599 · NINDS · OHIO STATE UNIVERSITY · PI BANKIEWICZ, KRYSTOF S, MURTHY, NIREN · 2019 to 2021
$2.3M
Single-Cell Transcriptomics of Non-Activated Latently Infected T cells Isolated from HIV+ Drug UsersR61DA048444 · NIDA · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2019 to 2021
$2.0M
Treatment of Duchenne Muscular Dystrophy with Cas9 Protein Complexed to Gold NanoparticlesR01EB023776 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONBOY, IRINA M, MURTHY, NIREN · 2017 to 2020
$1.4M
Maltose Targeted AntibioticsR33AI119115 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI MURTHY, NIREN, RILEY, LEE W · 2017 to 2019
$1.4M
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
FIC NIH HHS D43 TW010540NHGRI NIH HHS U24 HG010423NIAID NIH HHS R01 AI117064NIAID NIH HHS R33 AI119115NIBIB NIH HHS R01 EB023776NIDA NIH HHS R61 DA048444NIH HHS S10 OD024998NINDS NIH HHS UG3 NS115599
6 · The paper itself

Abstract

This article reports the synthesis and characterization of a novel self-immolative linker, based on thiocarbonates, which releases a free thiol upon activation

Indexed as

Molecular StructureNitroreductasesPenicillin AmidaseSpectrometry, FluorescenceSulfhydryl CompoundsNitroreductasesPenicillin AmidaseSulfhydryl Compounds

Identifiers

PMID35170593
PMCPMC9097719

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.