Evidence map›Paper›PMID 35170385›Full record

ArticleRenal failure2022

MiR-122-5p promotes peritoneal fibrosis in a rat model of peritoneal dialysis by targeting Smad5 to activate Wnt/β-catenin pathway.

Yirong Liu, Zhihong Ma, Zhenxing Huang, Dongmei Zou, Junbin Li, Ping Feng

Open access · goldAbstract read
In one paragraph

Article in Renal failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yirong LiuDepartment of Nephrology, Xining No.1 People's Hospital, Xining, PR China.
Zhihong MaDepartment of Nephrology, Xining No.1 People's Hospital, Xining, PR China.
Zhenxing HuangDepartment of Nephrology, Xining No.1 People's Hospital, Xining, PR China.
Dongmei ZouDepartment of Endocrinology, Xining No.1 People's Hospital, Xining, PR China.
Junbin LiDepartment of Nephrology, Xining No.1 People's Hospital, Xining, PR China.
Ping FengDepartment of Endocrinology, Xining No.1 People's Hospital, Xining, PR China.
Qinghai No.3 People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritoneal fibrosis (PF) is the main reason leading to declining efficiency and ultrafiltration failure of peritoneum, which restricts the application of peritoneal dialysis (PD). We aimed to investigate the effects and mechanisms of miR-122-5p on the PF. Sprague-Dawley (SD) rats were infused with glucose-based standard PD fluid to establish PF model. HE staining was performed to evaluate the extent of PF. Real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) and fluorescence

Indexed as

Animalsbeta CateninCadherinsEpithelial-Mesenchymal TransitionHumansIn Situ Hybridization, FluorescenceMicroRNAsModels, AnimalPeritoneal DialysisPeritoneal FibrosisRatsRats, Sprague-DawleySmad5 ProteinTransforming Growth Factor beta1VimentinWnt Signaling Pathwaybeta CateninCadherinsMicroRNAsMIRN122 microRNA, ratSmad5 ProteinSmad5 protein, ratTransforming Growth Factor beta1Vimentinepithelial–mesenchymal transition (EMT)MiR-122-5pPeritoneal fibrosisSmad5Wnt/β-catenin

Identifiers

PMID35170385
PMCPMC8856067
OpenAlexW4212797316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.