ArticleJournal of cachexia, sarcopenia and muscle2022
Phenotypic differences between people varying in muscularity.
Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- From neck to abdomen: cervical (C3) muscle quantification as a surrogate to lumbar (L3) sarcopenia assessment in head and neck cancer: systematic review and meta-analysis.Skeletal radiology · 2026Pooled it
- Sarcopenia as a prognostic marker in patients undergoing pancreaticoduodenectomy: an updated meta-analysis.Frontiers in oncology · 2025Pooled it
- The metabolic effects of habitual leg shaking: A randomized crossover trial.Journal of diabetes · 2024Trial
- Smartphone prediction of skeletal muscle mass: model development and validation in adults.The American journal of clinical nutrition · 2023Trial
- Defining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity.Journal of cachexia, sarcopenia and muscle · 2026Review
- Impact of creatine supplementation on kidney health: a systematic review and meta-analysis.International urology and nephrology · 2026Review
- Role of Fat-Free Mass-Adjusted Cardiorespiratory Fitness in Predicting Hospitalization Risk in Patients with Heart Failure.Yonsei medical journal · 2026Article
- Factors of pre-existing low muscle mass and its relationship with mortality in critically ill patients: a sex-specific analysis.Frontiers in medicine · 2026Article
- Impaired Glucose Tolerance and Altered Body Composition in Obese Young Adults: A Case-Control Study.Biomedicines · 2025Article
- Association of menarche, menopause, and reproductive history with cognitive performance in older US women: a cross-sectional study from NHANES 2011-2014.BMC public health · 2025Article
- Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Article
- Multimorbidity and the risk of malnutrition, frailty and sarcopenia in adults with cancer in the UK Biobank.Journal of cachexia, sarcopenia and muscle · 2024Article
- Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure.The Journal of clinical endocrinology and metabolism · 2023Article
- Physiology of sedentary behavior.Physiological reviews · 2023Review
- Low muscle mass, malnutrition, sarcopenia, and associations with survival in adults with cancer in the UK Biobank cohort.Journal of cachexia, sarcopenia and muscle · 2023Article
- Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution.Nutrients · 2023Article
- DJournal of cachexia, sarcopenia and muscle · 2022Review
- Phase angle obtained via bioelectrical impedance analysis and objectively measured physical activity or exercise habits.Scientific reports · 2022Article
- A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation.iScience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundBody mass is the primary metabolic compartment related to a vast number of clinical indices and predictions. The extent to which skeletal muscle (SM), a major body mass component, varies between people of the same sex, weight, height, and age is largely unknown. The current study aimed to explore the magnitude of muscularity variation present in adults and to examine if variation in muscularity associates with other body composition and metabolic measures.
methodsMuscularity was defined as the difference (residual) between a person's actual and model-predicted SM mass after controlling for their weight, height, and age. SM prediction models were developed using data from a convenience sample of 492 healthy non-Hispanic (NH) White adults (ages 18-80 years) who had total body SM and SM surrogate, appendicular lean soft tissue (ALST), measured with magnetic resonance imaging and dual-energy X-ray absorptiometry, respectively; residual SM (SM
resultsThe SM, on average, constituted the largest fraction of body weight in men and women up to respective BMIs of 35 and 25 kg/m
conclusionsMuscle mass is the largest body compartment in most adults without obesity and is widely variable in mass across people of similar body size and age; and high muscularity is accompanied by distinct body composition and metabolic characteristics. This previously unrecognized heterogeneity in muscularity in the general population has important clinical and research implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.