ArticleJournal of biomedical materials research. Part A2022
Prevention of medical device infections via multi-action nitric oxide and chlorhexidine diacetate releasing medical grade silicone biointerfaces.
Article in Journal of biomedical materials research. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Investigation of the susceptibility of clinical infection loads to nitric oxide antibacterial treatment.Nitric oxide : biology and chemistry · 2025Article
- Engineering Nitric Oxide-Releasing Antimicrobial Dental Coating for Targeted Gingival Therapy.ACS applied bio materials · 2024Article
- Development of a solid-supported light-triggered nitric oxide donor.Journal of photochemistry and photobiology. A, Chemistry · 2024Article
- Biomimetic catheter surface with dual action NO-releasing and generating properties for enhanced antimicrobial efficacy.Journal of biomedical materials research. Part A · 2023Article
- Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials.ACS materials Au · 2022Review
- Long-Term Storage Stability and Nitric Oxide Release Behavior of (ACS applied materials & interfaces · 2022Article
- Nitric Oxide Release and Antibacterial Efficacy Analyses ofACS applied bio materials · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The presence of bacteria and biofilm on medical device surfaces has been linked to serious infections, increased health care costs, and failure of medical devices. Therefore, antimicrobial biointerfaces and medical devices that can thwart microbial attachment and biofilm formation are urgently needed. Both nitric oxide (NO) and chlorhexidine diacetate (CHXD) possess broad-spectrum antibacterial properties. In the past, individual polymer release systems of CHXD and NO donor S-nitroso-N-acetylpenicillamine (SNAP) incorporated polymer platforms have attracted considerable attention for biomedical/therapeutic applications. However, the combination of the two surfaces has not yet been explored. Herein, the synergy of NO and CHXD was evaluated to create an antimicrobial medical-grade silicone rubber. The 10 wt% SNAP films were fabricated using solvent casting with a topcoat of CHXD (1, 3, and 5 wt%) to generate a dual-active antibacterial interface. Chemiluminescence studies confirmed the NO release from SNAP-CHXD films at physiologically relevant levels (0.5-4 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.