Evidence map›Paper›PMID 35170180›Full record

ArticleAging cell2022

Aging alters the metabolic flux signature of the ER-unfolded protein response in vivo in mice.

Catherine P Ward, Lucy Peng, Samuel Yuen, John Halstead, Hector Palacios, Edna Nyangau, Hussein Mohammed, Naveed Ziari, Mohamad Dandan, Ashley E Frakes and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Catherine P WardDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.ORCID 0000-0001-8539-0535
Lucy PengDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Samuel YuenDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
John HalsteadDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Hector PalaciosDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Edna NyangauDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Hussein MohammedDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Naveed ZiariDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Mohamad DandanDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Ashley E FrakesDepartment of Molecular and Cellular Biology, University of California, Berkeley, California, USA.
Holly K GildeaDepartment of Molecular and Cellular Biology, University of California, Berkeley, California, USA.
Andrew DillinDepartment of Molecular and Cellular Biology, University of California, Berkeley, California, USA.
Marc K HellersteinDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
University of California, Berkeley · US

Funding

Neuroscience Training Program at UC BerkeleyT32NS095939 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BATEUP, HELEN S. · 2016 to 2025
$6.3M
NINDS NIH HHS T32 NS095939
6 · The paper itself

Abstract

Age is a risk factor for numerous diseases, including neurodegenerative diseases, cancers, and diabetes. Loss of protein homeostasis is a central hallmark of aging. Activation of the endoplasmic reticulum unfolded protein response (UPR

Indexed as

Endoplasmic Reticulum StressUnfolded Protein ResponseAnimalsMiceSignal TransductionTriglyceridesTriglyceridesagingde novo lipogenesisendoplasmic reticulumproteome dynamicsproteomicsunfolded protein response

Identifiers

PMID35170180
PMCPMC8920450
OpenAlexW4213018174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.