Evidence map›Paper›PMID 35170026›Full record

Observational studyActa anaesthesiologica Scandinavica2022

Continuous monitoring of vital sign abnormalities; association to clinical complications in 500 postoperative patients.

Camilla Haahr-Raunkjaer, Jesper Mølgaard, Mikkel Elvekjaer, Søren M Rasmussen, Michael P Achiam, Lars N Jorgensen, Mette I V Søgaard, Katja K Grønbaek, Anne-Britt Oxbøll, Helge B D Sørensen and 2 more

Registry-linked trialOpen access · hybridAbstract readObservational Study
In one paragraph

Observational study in Acta anaesthesiologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03491137 (Wireless Assessment of Respiratory and Circulatory Distress in Surgical Patients), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03491137 completednot on this map

Wireless Assessment of Respiratory and Circulatory Distress in Surgical Patients

Typeobservational_patient_registrySponsorBispebjerg HospitalRan2018 to 2021Enrolled505ConditionsPostoperative Complications
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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  14. Time-sequential prediction of postoperative complications after gastric cancer surgery using machine learning: a multicenter cohort study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Camilla Haahr-RaunkjaerDepartment of Anaesthesiology, Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8646-5666
Jesper MølgaardDepartment of Anaesthesiology, Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2062-9570
Mikkel ElvekjaerDepartment of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3601-8432
Søren M RasmussenBiomedical Engineering, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-6297-2871
Michael P AchiamDepartment of Surgical Gastroenterology, Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3062-5138
Lars N JorgensenDigestive Disease Centre, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7465-5374
Mette I V SøgaardDepartment of Anaesthesiology, Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Katja K GrønbaekDepartment of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3045-6909
Anne-Britt OxbøllDepartment of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0331-6513
Helge B D SørensenBiomedical Engineering, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0001-5716-7600
Christian S MeyhoffDepartment of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4885-4609
Eske K AasvangDepartment of Anaesthesiology, Centre for Cancer and Organ Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7131-2461
University of Copenhagen · DKTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients undergoing major surgery are at risk of complications, so-called serious adverse events (SAE). Continuous monitoring may detect deteriorating patients by recording abnormal vital signs. We aimed to assess the association between abnormal vital signs inspired by Early Warning Score thresholds and subsequent SAEs in patients undergoing major abdominal surgery.

methodsProspective observational cohort study continuously monitoring heart rate, respiratory rate, peripheral oxygen saturation, and blood pressure for up to 96 h in 500 postoperative patients admitted to the general ward. Exposure variables were vital sign abnormalities, primary outcome was any serious adverse event occurring within 30 postoperative days. The primary analysis investigated the association between exposure variables per 24 h and subsequent serious adverse events.

resultsSerious adverse events occurred in 37% of patients, with 38% occurring during monitoring. Among patients with SAE during monitoring, the median duration of vital sign abnormalities was 272 min (IQR 110-447), compared to 259 min (IQR 153-394) in patients with SAE after monitoring and 261 min (IQR 132-468) in the patients without any SAE (p = .62 for all three group comparisons). Episodes of heart rate ≥110 bpm occurred in 16%, 7.1%, and 3.9% of patients in the time before SAE during monitoring, after monitoring, and without SAE, respectively (p < .002). Patients with SAE after monitoring experienced more episodes of hypotension ≤90 mm Hg/24 h (p = .001).

conclusionOverall duration of vital sign abnormalities at current thresholds were not significantly associated with subsequent serious adverse events, but more patients with tachycardia and hypotension had subsequent serious adverse events.

trial registrationClinicaltrials.gov, identifier NCT03491137.

Indexed as

HypotensionVital SignsHumansMonitoring, PhysiologicProspective StudiesRespiratory Rateabnormal vital signscontinuous monitoringearly warning scorepostoperative complicationsserious adverse eventswearablewireless devices

Identifiers

PMID35170026
PMCPMC9310747
OpenAlexW4212897849

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.