Evidence map›Paper›PMID 35169982›Full record

ArticleJournal of cancer survivorship : research and practice2023

Disparities in fertility preservation use among adolescent and young adult women with cancer.

Clare Meernik, Stephanie M Engel, Ally Wardell, Christopher D Baggett, Parul Gupta, Nidia Rodriguez-Ormaza, Barbara Luke, Valerie L Baker, Ethan Wantman, Jose Alejandro Rauh-Hain and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Fertility in breast cancer survivorship: a scoping review.Journal of cancer survivorship : research and practice · 2026
    Review
  3. Perceived Versus Demonstrated Oncofertility Knowledge Among Oncology Providers.Journal of adolescent and young adult oncology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Fertility Information Perceptions and Needs of People with Cancer, Their Family Members, and Caregivers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Clare MeernikDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 135 Dauer Dr., Chapel Hill, NC, 27599, USA. cmeernik@email.unc.edu.ORCID 0000-0002-8564-1266
Stephanie M EngelDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 135 Dauer Dr., Chapel Hill, NC, 27599, USA.
Ally WardellDepartment of Biostatistics, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC, USA.
Christopher D BaggettDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 135 Dauer Dr., Chapel Hill, NC, 27599, USA.
Parul GuptaLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Nidia Rodriguez-OrmazaDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 135 Dauer Dr., Chapel Hill, NC, 27599, USA.
Barbara LukeDepartment of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
Valerie L BakerDivision of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ethan WantmanRedshift Technologies, Inc., New York, NY, USA.
Jose Alejandro Rauh-HainDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jennifer E MersereauDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Andrew F OlshanDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 135 Dauer Dr., Chapel Hill, NC, 27599, USA.
Andrew B SmithermanDepartment of Pediatrics and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Jianwen CaiDepartment of Biostatistics, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC, USA.
Hazel B NicholsDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, 135 Dauer Dr., Chapel Hill, NC, 27599, USA.
University of North Carolina at Chapel Hill · USJohns Hopkins University · USMichigan State University · USThe University of Texas MD Anderson Cancer Center · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
LINEBERGER CANCER CONTROL EDUCATION PROGRAMR25CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EARP, JO ANNE L, RIBISL, KURT M. · 1992 to 2016
$8.0M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
Clinical Pregnancy Outcomes in Adolescent and Young Adult Female Cancer SurvivorsR01CA204258 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLS, HAZEL B · 2017 to 2021
$3.4M
In vitro fertilization outcomes after cancerR01CA211093 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LUKE, BARBARA JOAN, NICHOLS, HAZEL B · 2019 to 2023
$1.9M
Assisted Reproductive Technology Use After Adolescent and Young Adult Cancer in North CarolinaF31CA260787 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEERNIK, CLARE E · 2021 to 2021
$36k
NCI NIH HHS F31 CA260787NCI NIH HHS R01 CA204258NCI NIH HHS R01 CA211093NCI NIH HHS T32 CA057726NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

purposeWomen face multiple barriers to fertility preservation after cancer diagnosis, but few studies have examined disparities in use of these services.

methodsWomen aged 15-39 years diagnosed with cancer during 2004-2015 were identified from the North Carolina Central Cancer Registry and linked to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System. Women who cryopreserved oocytes or embryos for fertility preservation (n = 96) were compared to women who received gonadotoxic treatment but did not use fertility preservation (n = 7964). Conditional logistic and log-binomial regression were used to estimate odds ratios (ORs) or prevalence ratios (PRs) and 95% confidence intervals (CIs).

resultsFew adolescent and young adult women with cancer in our study (1.2%) used fertility preservation. In multivariable regression, women less likely to use fertility preservation were older at diagnosis (ages 25-29 vs. 35-39: OR = 6.27, 95% CI: 3.35, 11.73); non-Hispanic Black (vs. non-Hispanic White: PR = 0.44, 95% CI: 0.24, 0.79); and parous at diagnosis (vs. nulliparous: PR = 0.24, 95% CI: 0.13, 0.45); or lived in census tracts that were non-urban (vs. urban: PR = 0.12, 95% CI: 0.04, 0.37) or of lower socioeconomic status (quintiles 1-3 vs. quintiles 4 and 5: PR = 0.39, 95% CI: 0.25, 0.61).

conclusionsWomen with cancer who were older, non-Hispanic Black, parous, or living in areas that were non-urban or of lower socioeconomic position were less likely to use fertility preservation. IMPLICATIONS FOR CANCER SURVIVORS: Clinical and policy interventions are needed to ensure equitable access to fertility services among women facing cancer treatment-related infertility.

Indexed as

Cancer SurvivorsFertility PreservationInfertilityNeoplasmsCryopreservationFemaleHumansCancer survivorsCryopreservationFemaleFertility preservation

Identifiers

PMID35169982
PMCPMC9378772
OpenAlexW4212948146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.