Evidence map›Paper›PMID 35169906›Full record

ArticleAnalytical and bioanalytical chemistry2022

Electrochemical immunosensors using electrodeposited gold nanostructures for detecting the S proteins from SARS-CoV and SARS-CoV-2.

Laís Canniatti Brazaca, Amanda Hikari Imamura, Nathalia Oezau Gomes, Mariana Bortholazzi Almeida, Desirée Tamara Scheidt, Paulo A Raymundo-Pereira, Osvaldo N Oliveira, Bruno Campos Janegitz, Sergio Antonio Spinola Machado, Emanuel Carrilho

Open access · bronzeAbstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 83 citations in OpenAlex.

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  14. Study of VACS applied materials & interfaces · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Laís Canniatti BrazacaInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil. lais.brazaca@usp.br.
Amanda Hikari ImamuraInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil.
Nathalia Oezau GomesInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil.
Mariana Bortholazzi AlmeidaInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil.
Desirée Tamara ScheidtInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil.
Paulo A Raymundo-PereiraInstituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil.
Osvaldo N OliveiraInstituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil.
Bruno Campos JanegitzDepartamento de Ciências da Natureza, Matemática e Educação, Universidade Federal de São Carlos, Araras, SP, 13600-970, Brazil.
Sergio Antonio Spinola MachadoInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil.
Emanuel CarrilhoInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil. emanuel@iqsc.usp.br.
Universidade de São Paulo · BRUniversidade Federal de São Carlos · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 164569/2020-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 303338/2019-9Conselho Nacional de Desenvolvimento Científico e Tecnológico 315824/2020-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 423952/2018-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 465389/2014-7Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 3007/2014 - PROCADCoordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.504861/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/40867-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/01919-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/05362-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/21097-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/19750-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/22214-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/01777-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/09587-8
6 · The paper itself

Abstract

This paper reports the development of a low-cost (< US$ 0.03 per device) immunosensor based on gold-modified screen-printed carbon electrodes (SPCEs). As a proof of concept, the immunosensor was tested for a fast and sensitive determination of S proteins from both SARS-CoV and SARS-CoV-2, by a single disposable device. Gold nanoparticles were electrochemically deposited via direct reduction of gold ions on the electrode using amperometry. Capture antibodies from spike (S) protein were covalently immobilized on carboxylic groups of self-assembled monolayers (SAM) of mercaptoacetic acid (MAA) attached to the gold nanoparticles. Label-free detection of S proteins from both SARS-CoV and SARS-CoV-2 was performed with electrochemical impedance spectroscopy (EIS). The immunosensor fabricated with 9 s gold deposition had a high performance in terms of selectivity, sensitivity, and low limit of detection (LOD) (3.16 pmol L

Indexed as

Biosensing TechniquesCOVID-19Metal NanoparticlesNanostructuresSevere acute respiratory syndrome-related coronavirusElectrochemical TechniquesElectrodesGoldHumansImmunoassayLimit of DetectionSARS-CoV-2GoldDiagnosisGold nanoparticlesImmunosensorSARS-CoVSARS-CoV-2S protein

Identifiers

PMID35169906
PMCPMC8853172
OpenAlexW4213035053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.